Beilstein J. Org. Chem.2022,18, 360–367, doi:10.3762/bjoc.18.40
Abstract Four new phenolic siderophores were isolated from the actinomycete Nocardia altamirensis along with the known natural product amamistatin B and a putative biosynthetic shunt product. The structures of all compounds were elucidated through 1D and 2D NMR analyses as well as mass spectrometry. The
iron-chelating properties of the retrieved metabolites were evaluated in a chrome azurol S assay.
Keywords: actinomycete; amamistatin; Nocardia; siderophore; structure elucidation; Introduction
Iron is known to easily interconvert between a reduced ferrous (Fe2+) and an oxidized ferric state (Fe3
bacterium Nocardia altamirensis DSM 44997, which had originally been isolated from a microbial cave wall community and represents a non-pathogenic strain [5]. Our analysis led to the identification of six iron-chelating molecules belonging to the amamistatin family. Four of these compounds (1–4) have not
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Graphical Abstract
Figure 1:
Chemical structures of amamistatins (1–5) and a putative biosynthetic shunt product (6) isolated in...