Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides

• Alexander S. Budnikov,
• Nikita E. Leonov,
• Michael S. Klenov,
• Andrey A. Kulikov,
• Igor B. Krylov,
• Timofey A. Kudryashev,
• Aleksandr M. Churakov,
• Alexander O. Terent’ev and
• Vladimir A. Tartakovsky

Beilstein J. Org. Chem. 2025, 21, 2739–2754, doi:10.3762/bjoc.21.211

• , Russian Federation 10.3762/bjoc.21.211 Abstract An atom- and step-economical electrochemical method for the synthesis of aliphatic nitro-NNO-azoxy compounds from the corresponding nitroso compounds was developed employing ammonium dinitramide, a prospective green oxidant for aerospace propulsion

• phytopathogenic fungi. Keywords: ammonium dinitramide; antifungal agents; azoxy compounds; electrosynthesis; NO donors; Introduction Organic compounds containing N–N and N–O bonds are ubiquitous in diverse fields, including pharmaceuticals, agrochemicals, natural products [1][2][3][4], as well as in

• group developed a one-step electrochemical approach to the synthesis of nitro-NNO-azoxy arenes employing ammonium dinitramide (ADN) [87]. The achieved use of ADN, known as prospective chlorine-free green oxidant for aerospace propulsion applications [89][90][91], as both a reagent and an electrolyte is