The high potential of methyl laurate as a recyclable competitor to conventional toxic solvents in [3 + 2] cycloaddition reactions

• Ayhan Yıldırım and
• Mustafa Göker

Beilstein J. Org. Chem. 2025, 21, 2389–2415, doi:10.3762/bjoc.21.184

• that the isolation procedures employed in these studies to obtain the product from the aqueous reaction medium are time-consuming and inefficient. In this study, when water was used as a solvent, a similar problem was encountered to the one mentioned below, and the yield of the product was

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides

• Md Imran Hossain,
• Md Imdadul H. Khan,
• Seong Jong Kim and
• Hoang V. Le

Beilstein J. Org. Chem. 2022, 18, 446–458, doi:10.3762/bjoc.18.47

• -fluoro-N-hydroxybenzimidoyl chloride (1a) and 1-phenylbutane-1,3-dione (2a) (Table 1) as the starting materials and a water–methanol mixture as the aqueous reaction medium. A series of organic and inorganic bases was screened at room temperature in various combinations of water–methanol mixtures and

An effective Pd nanocatalyst in aqueous media: stilbene synthesis by Mizoroki–Heck coupling reaction under microwave irradiation

• Carolina S. García,
• Paula M. Uberman and
• Sandra E. Martín

Beilstein J. Org. Chem. 2017, 13, 1717–1727, doi:10.3762/bjoc.13.166

• make this protocol a great option for stilbene syntheses by Mizoroki–Heck reaction. Keywords: aqueous reaction medium; MAOS; Mizoroki–Heck reaction; Pd nanoparticle; sustainable organic synthesis; Introduction Palladium-catalyzed reactions have emerged as an important tool for organic synthesis