A combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines

• Erli Sugiono and
• Magnus Rueping

Beilstein J. Org. Chem. 2013, 9, 2457–2462, doi:10.3762/bjoc.9.284

Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach

• Pankaj Chauhan and
• Swapandeep Singh Chimni

Beilstein J. Org. Chem. 2012, 8, 2132–2141, doi:10.3762/bjoc.8.240

• methods for the development of environmentally benign chemical transformations. Recently, the use of these mechanochemical techniques in asymmetric organocatalysis has increased. This review highlights the progress in asymmetric organocatalytic reactions assisted by mechanochemical techniques. Keywords

• amplified in recent times. In this regard, catalytic asymmetric synthesis involving the use of chiral organocatalysts has emerged as a powerful tool from the infancy to the maturity of asymmetric organocatalysis [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The use of organocatalysts for

• , which helps in the easy isolation of products. Besides the significant progress in the application of mechanochemical techniques in asymmetric organocatalysis, there exists a lot of scope for other asymmetric reactions ranging from simple carbon–carbon, and carbon–heteroatom bond formation to more

Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis

• Marcus Frings,
• Isabelle Thomé and
• Carsten Bolm

Beilstein J. Org. Chem. 2012, 8, 1443–1451, doi:10.3762/bjoc.8.164

• hydrogenations and carbon–carbon bond formations [34][35][36]. During the past decade, asymmetric organocatalysis had a tremendous impact on synthetic organic chemistry [37][38][39][40][41]. Yet, this field of research continues to grow, and the quest for new organic molecules which efficiently catalyze

• (-like) catalysts with S-stereogenic sulfonimidoyl substituents are unknown. Herein, we present our first results concerning synthetic approaches towards such molecules and describe preliminary studies of two applications in asymmetric organocatalysis. Results and Discussion Our investigations began with

• leading to a dihydropyrimidinone. In the future we aim to expand the scope of the chiral sulfonimidoyl-containing thiourea framework and hope to find more applications of these interesting molecules in asymmetric organocatalysis. General structure of sulfoximines 1 and one of the enantiomers of S-methyl-S

Organocatalytic C–H activation reactions

• Subhas Chandra Pan

Beilstein J. Org. Chem. 2012, 8, 1374–1384, doi:10.3762/bjoc.8.159

• non-asymmetric and asymmetric C–H activation reactions mediated by organocatalysts are discussed in this review. Keywords: asymmetric; C–H activation; non-asymmetric; organocatalysis; organocatalytic; Introduction C–H activation reactions have recently been found to be a powerful method for the

Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins

• Hang Zhang,
• Shan-Jun Zhang,
• Qing-Qing Zhou,
• Lin Dong and
• Ying-Chun Chen

Beilstein J. Org. Chem. 2012, 8, 1241–1245, doi:10.3762/bjoc.8.139

• yields (up to 97%). Keywords: allylic amination; asymmetric organocatalysis; Morita–Baylis–Hillman carbonates; 2-oxindoles; quaternary chiral center; Introduction Chiral 3-amino-2-oxindoles are versatile and useful units for the preparation of natural products and drug candidates, such as the

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.0^2,6]decane skeleton

• Matthias Breuning,
• Tobias Häuser,
• Christian Mehler,
• Christian Däschlein,
• Carsten Strohmann,
• Andreas Oechsner and
• Holger Braunschweig

Beilstein J. Org. Chem. 2009, 5, No. 81, doi:10.3762/bjoc.5.81

• β-turn-inducing building blocks in peptidomimetics and for chiral auxiliaries in asymmetric organocatalysis. Keywords: amino acid; enantioselective synthesis; norbornane; polycyclic compounds; pyrrolidine; Introduction Unnatural amino acids with a rigid bowl-shaped backbone have received