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Search for "aurone" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.

A golden opportunity: benzofuranone modifications of aurones and their influence on optical properties, toxicity, and potential as dyes

  • Joza Schmitt and
  • Scott T. Handy

Beilstein J. Org. Chem. 2019, 15, 1781–1785, doi:10.3762/bjoc.15.171

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  • . In this study, the influence of substitution in the benzofuranone ring on the UV–vis spectrum is explored, as well as an initial screening of their toxicity and a qualitative preliminary study of their potential to act as fabric dyes. Keywords: aurone; dyeing; dyes; substitution effect; toxicity; UV
  • to develop and validate the method for the rational design of new aurone fluorophores [5]. Two more recent studies have explored the influence of the benzofuranone portion of the aurone system. Salas examined a larger set of compounds featuring methoxy substitution at 4 or 5-position on the
  • . Muñoz-Becerra and co-workers have also reported a computational study of amino aurone derivatives with variations in the benzofuranone portion of the molecule, though all substitution was strictly at the 4-position of the benzofuranone [7]. As an extension of our on-going studies of the aurone ring
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Published 25 Jul 2019

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

  • Franziska Hemmerling and
  • Frank Hahn

Beilstein J. Org. Chem. 2016, 12, 1512–1550, doi:10.3762/bjoc.12.148

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  • they differ by a central, annelated furan-3-one moiety instead of an acrylate unit (Scheme 25) [149]. Their biosynthesis proceeds from chalcones by an oxidation–conjugate addition cascade catalysed by plant phenol oxidases (PPOs) [150][151]. The PPO aureusidin synthase plays a central role in aurone
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Published 20 Jul 2016

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

  • Todd J. Eckroat,
  • Abdelrahman S. Mayhoub and
  • Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

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  • resulted in a variety of radiolabeled molecular probes for in vivo PET/SPECT imaging. The scaffolds from which these newer radiolabeled probes are derived include chalcone (5) and its conformationally restricted analogues flavone (6) and aurone (7); stilbene (8) and its analogues diphenyl-1,2,4-oxadiazole
  • and 30b were also prepared by using the procedure described for the synthesis of the [Re]- and [99mTc]-labeled chalcones 20a and 20b (Scheme 2). The [99mTc]-labeled flavone complex 30a displayed high Aβ plaque affinity but limited brain uptake [18]. Aurone derivatives have been investigated for their
  • Aβ plaque binding affinity [19]. The [125I]-labeled methylamine aurone 31a presented great binding affinity to Aβ aggregates (Ki = 1.2 nM), better than all reported flavones to date. It also showed rapid brain uptake rate (3.17% ID/g at 2 min) and rapid clearance (0.24% ID/g at 60 min) [19]. The
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Published 28 May 2013
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