Beilstein J. Org. Chem.2021,17, 1591–1599, doi:10.3762/bjoc.17.113
Institute for Sustainable Chemistry (WISCh), Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen, Germany 10.3762/bjoc.17.113 Abstract The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N-2
: benzhydrazides; copper; 3-methyleneisoindolin-1-one; removable directing group; Introduction
Inexpensive copper-promoted oxidative C−H activations [1][2][3][4][5][6][7][8][9][10][11] have been recognized as competent tools for the efficient assembly and late-stage functionalization of organic molecules due to
reaction was performed under a nitrogen atmosphere, the efficacy was significantly decreased (Table 1, entry 18).
We next examined the versatility of the copper-promoted ethynylbenzene (2a) annulation with various benzhydrazides 1 under the optimized reaction conditions (Scheme 1). To our delight
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Graphical Abstract
Figure 1:
Assembly of 3-methyleneisoindolin-1-one via 3d transition metal-mediated/catalyzed oxidative C−H/N−...