Beilstein J. Org. Chem.2020,16, 1456–1464, doi:10.3762/bjoc.16.121
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Keywords: benzo[a]quinolizidinones; Castagnoli–Cushman reaction; 3,4-dihydroisoquinolines; monocyclic anhydrides; pyrrolo[2,1-a]isoquinolinones; Introduction
The benzo[a]quinolizidine ring system is an important heterocyclic framework found in natural products and prospective pharmaceuticals [1]. This
substituted benzo[a]quinolizidinones and pyrrolo[2,1-a]isoquinolinones. This reaction also would allow the construction of bioisosteric oxygen and sulfur derivatives of the target heterocyclic framework.
Results and Discussion
Our synthetic strategy relied on the possibility to form ring C of the target ring
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Graphical Abstract
Figure 1:
Compounds comprising a benzo[a]quinolizidine ring system.