Beilstein J. Org. Chem.2011,7, 1007–1013, doi:10.3762/bjoc.7.114
[3.3.1]alkanones in yields ranging from 48–93%.
Keywords: bicyclo[3.3.1]nonenone; carbocyclization; Diels–Alder; gold catalysis; one-pot process; Introduction
Highly oxygenated and densely substituted carbon-bridged medium sized rings such as 1 are commonly found in nature as structural frameworks of
, which upon exposure to the Au(I) complex 6 (2 mol %) provided the desired bicyclo[3.3.1]nonenone 11 in 88% yield. It is important to note that the Au(I)-catalyzed cyclization proceeds in high yields in a sterically congested environment. The synthesis of the core of papuaforin (11) was achieved in five
steps from enone 8.
However, one might recognize that the low chemical yields encountered in some steps undermine the efficacy of the Au(I)-catalyzed cyclization approach. In order to solve this issue, we assumed that bicyclo[3.3.1]nonenone scaffolds can be directly obtained through an intermolecular
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Graphical Abstract
Figure 1:
Structures of naturally occurring PPAPs.