Beilstein J. Org. Chem.2018,14, 1016–1020, doi:10.3762/bjoc.14.87
; biheterocycles; hypervalent iodine; iodine; oxidatively assisted esterification; Introduction
In recent years, the interest in heterocyclic organohypervalent iodine compounds has experienced an unprecedented growth [1][2][3][4][5][6]. A variety of new hypervalent iodine heterocycles have been prepared, and
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Graphical Abstract
Scheme 1:
Representative examples of benziodoxoles and benziodazoles.
Beilstein J. Org. Chem.2012,8, 1901–1908, doi:10.3762/bjoc.8.220
nortopsentins [21][22][23]), dihydroimidazole (discodermindole [24]), oxadiazine (alboinon [25]), piperazine (dragmacidon [26]), maleimide (didemidines [25]), and pyrimidine (meridianins) [27][28][29]. Among these, meridianins (Figure 1), the tethered biheterocycles isolated from the south Atlantic tunicate
-based alkaloid meridianins into annulated indole-based polyheterocycles as novel chemprobes.
For the synthesis of meridianin-inspired indole-based annulated polyheterocycles, we proposed to transform tethered biheterocycles into β-carboline-based polyheterocycles, a new prototype hitherto not reported