Search results
Search for "bioassay" in Full Text gives 34 result(s) in Beilstein Journal of Organic Chemistry.
Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)
Beilstein J. Org. Chem. 2013, 9, 447–452, doi:10.3762/bjoc.9.47
- , P.O. Box 812 Yaoundé, Cameroon Behavioural and Chemical Ecology Department, International Centre for Insect Physiology and Ecology, P.O. Box 30772, Nairobi 00100, Kenya 10.3762/bjoc.9.47 Abstract The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of
- often harmful to nontarget organisms, including human beings, and have negative environmental impacts. We herein report the bioassay-guided isolation of four compounds including three new ones and the larvicidal activity of two of them. Results and Discussion Stem bark of Z. paracanthum was successively
Synthesis and testing of the first azobenzene mannobioside as photoswitchable ligand for the bacterial lectin FimH
Beilstein J. Org. Chem. 2013, 9, 223–233, doi:10.3762/bjoc.9.26
- the azobenzene moiety and the tyrosine gate at the entrance of the CRD, though in different ways. The only difference that is seen is that, apparently, the interactions of mannobioside 2 with the open-gate conformation of FimH are advantageous over those with the closed-gate form. From the bioassay in
- 56: Photoisomerization studies, UV–vis spectra, NMR spectra, bioassay and docking results. Acknowledgements Financial support by the DFG (collaborative network SFB677) and FCI (Fonds der Chemischen Industrie) is gratefully acknowledged. We thank Max Britz for technical assistance.
Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics
Beilstein J. Org. Chem. 2012, 8, 1146–1160, doi:10.3762/bjoc.8.128
- bis(S-acylcysteine) 36 forming the pyridine–cysteine-containing macrocycle 40 in 70% yield (Scheme 3, see Supporting Information File 1 for experimental details). Bioassay Screening for antibacterial activity was performed for two cyclic peptidomimetics belonging to scaffold 37, namely 37a and 37b
Volatile organic compounds produced by the phytopathogenic bacterium Xanthomonas campestris pv. vesicatoria 85-10
Beilstein J. Org. Chem. 2012, 8, 579–596, doi:10.3762/bjoc.8.65
- concentrations. Surprisingly, undecan-2-one (31) promoted the growth of R. solani by 10–15% at concentrations from 0.01 to 10 μmol in 50 μL and dodecan-2-one (38) at 0.01 and 0.1 μmol in 50 μL. 10-Methylundecan-2-one (34) had no effect on the growth of R. solani. An additional bioassay, performed with a mixture
- experimental design of the bioassay was not appropriate or other volatiles account for the inhibitory effects. In the literature, contradictory results were found for undecan-2-one (31). It is likely to be involved in the inhibition of sapstain fungi [40], while Sclerotinia sclerotiorum was not affected by 31
- mixture (0.09–9 μmol) were applied on filter paper (1 cm2), which was deposited at the other compartment of the Petri dish. Control experiments were performed with pentane alone. Similarly to the cocultivation test, the bioassay with individual compounds was performed at 20 °C in the dark. Every 24 h the
Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla
Beilstein J. Org. Chem. 2012, 8, 283–289, doi:10.3762/bjoc.8.30
- -HETE 3 (1.7 µg/g agar), and a 1/1 mixture of 5 and 6 (total 8.2 µg/g agar). To evaluate the response of the sea snail E. peruviana towards the algal compounds, we developed a new bioassay based on the avoidance reaction of the snail. When the snails were put on a Petri dish that was partially filled
- 6) were incorporated into agar matrices in natural concentrations and the response of the snails was tested by using the attachment bioassay, as described above. Of the tested metabolites only 7,8-di-HETE (3) was active when applied at concentrations corresponding to those detected in wounded G
Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
Beilstein J. Org. Chem. 2011, 7, 1135–1140, doi:10.3762/bjoc.7.131
- ), r.t.; b. Pd/C, 5%, HCOONH4, MeOH/H2O, reflux. Supporting Information Supporting Information File 306: General information, procedures, spectral data of all compounds, results of bioassay, and copies of selected NMR spectra. Acknowledgements The study was partly supported by SB RAS-83, 88 and RFBR-09
Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation
Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123
- reported of the preparation and bioassay of pseudopeptides and peptidomimetics bearing difluoromethyl groups. For example, compound I can act as bradykinin B1 antagonist or inverse agonist and can be used in the prevention of inflammation and pain [19]. Compound II is an inhibitor of microsomal
(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study
Beilstein J. Org. Chem. 2009, 5, No. 12, doi:10.3762/bjoc.5.12
- actual toxic substance of these animals has remained unknown. We recently isolated a novel amphipathic substance, named complanine (Figure 1), from an amphinomid polychaete, Eurythoe complanata (Figure 2). Complanine has been identified as an inflammatory substance by bioassay-guided separations; and the
A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin- 4(3H)-ones
Beilstein J. Org. Chem. 2008, 4, No. 49, doi:10.3762/bjoc.4.49
- many cases compares favorably with other existing methods. The preliminary bioassay of the compounds indicated that the 2-amino-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-ones can be used as lead structure for developing novel fungicides. Further bioassay, optimization and structure-activity
Other Beilstein-Institut Open Science Activities
