Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles

• Kathrin Fiege,
• Heinrich Lünsdorf,
• Sevil Atarijabarzadeh and
• Petra Mischnick

Beilstein J. Org. Chem. 2012, 8, 551–566, doi:10.3762/bjoc.8.63

• biocompatibility, dextrans are applied as blood-plasma expander. Dextran derivatives are used in many biomedical and bioanalytical applications [34] and are the subject of further developments in this field [35]. Therefore, we selected pullulan and dextran as candidates for a linear and a branched polysaccharide

Hyperbranched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release

• Indra Böhm,
• Susanne Katharina Kreth and
• Helmut Ritter

Beilstein J. Org. Chem. 2011, 7, 1130–1134, doi:10.3762/bjoc.7.130

• ability to release molecules in response to temperature or pH change is an important feature of new biopharmaceutical compounds [6][7][8][9][10][11]. Hyperbranched polyethylenimine (PEI) is a promising material for medical applications due to its high biocompatibility [12][13]. Active drugs bearing

ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering

• Franziska Weichelt,
• Solvig Lenz,
• Stefanie Tiede,
• Ingrid Reinhardt,
• Bernhard Frerich and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2010, 6, 1199–1205, doi:10.3762/bjoc.6.137

• pore size and pore structure, biocompatibility, biodegradability or mechanical strength. Due to their unitary porous structure and the ease of synthesis via polymerization or consolidation processes, monolithic materials were introduced into the field of TE some years ago [6][7]. Several studies have

• scaffold materials in TE with specific properties, e.g., high mechanical strength and biocompatibility, we report here ROMP-derived cyclooctene-based monoliths reinforced with two of the most frequently used inorganic materials in nature, i.e., calcite and calcium hydroxyapatite [19], respectively. Results

• biocompatibility of the monolithic hybrid support as well as sufficient cell adhesion on the monolithic material. Conclusion COE-based monolithic scaffolds have been prepared via ROMP in the presence of two different types of inorganic nanoparticles. It was shown that variation of both the nanoparticle type and

Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels

• Andreea Pasc,
• Firmin Obounou Akong,
• Sedat Cosgun and
• Christine Gérardin

Beilstein J. Org. Chem. 2010, 6, 973–977, doi:10.3762/bjoc.6.109

• acid-based amphiphiles have been received much attention in the recent past on account of their biocompatibility and eco-friendly nature. Biologically inspired His-based surfactants are of particular interest not only for their antioxidant properties and their potential therapeutic effects, but also as

Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

• Gernot U. Marten,
• Thorsten Gelbrich and
• Annette M. Schmidt

Beilstein J. Org. Chem. 2010, 6, 922–931, doi:10.3762/bjoc.6.98

• , biocompatibility, and a tunable lower critical solution temperature (LCST) in water. The phase separation can alternatively be initiated by magnetic heating caused by magnetic losses in ac magnetic fields. The immobilization of porcine pancreas trypsin to the core–shell nanoparticles results in highly active

• heat generation, owing to its behavior in static and dynamic magnetic fields. The polymer shell is the anchor for covalent attachment of the enzyme, and allows the introduction of thermoresponsive behavior. At the same time, it improves biocompatibility and stabilization against agglomeration. Finally

• water. By proper choice of the copolymer composition, the thermoflocculation temperature of the core–shell particles can be adjusted [34][35]. The biocompatibility of poly(ethylene glycol) derivates is helpful to obtain nanoparticles acceptable for use in in vitro biological systems. The direct

Poly(glycolide) multi-arm star polymers: Improved solubility via limited arm length

• Florian K. Wolf,
• Anna M. Fischer and
• Holger Frey

Beilstein J. Org. Chem. 2010, 6, No. 67, doi:10.3762/bjoc.6.67

• polyesters such as polylactic acid (PLA) and poly(ε-caprolactone) [1] are of great interest due to their biodegradability, biocompatibility and permeability for many drugs. In contrast, poly(glycolic acid) (PGA) is scarcely used because of its high degree of crystallinity and its insolubility in all common