Search results
Search for "bioimaging" in Full Text gives 39 result(s) in Beilstein Journal of Organic Chemistry.
Synthesis of a water-soluble 2,2′-biphen[4]arene and its efficient complexation and sensitive fluorescence enhancement towards palmatine and berberine
Beilstein J. Org. Chem. 2018, 14, 2236–2241, doi:10.3762/bjoc.14.198
- as bioimaging and self-assembled drug delivery systems [33][34][35][36][37][38][39][40]. For example, our group demonstrated a direct host–guest complexation-based drug delivery system for oxaliplatin by carboxylatopillar[6]arene [36]. The encapsulation could not only improve the drug‘s stability in
Revisiting ring-degenerate rearrangements of 1-substituted-4-imino-1,2,3-triazoles
Beilstein J. Org. Chem. 2018, 14, 2098–2105, doi:10.3762/bjoc.14.184
- cations, and have impacted fields that include bioimaging [26][27] and chemosensing [28][29]. Surprisingly, the reported examples partnering 1,2,3-triazole and imine N-donor groups are limited [30][31][32], despite the ubiquity of such Schiff base subunits in coordination chemistry. 4-Iminotriazole
Rational design of boron-dipyrromethene (BODIPY) reporter dyes for cucurbit[7]uril
Beilstein J. Org. Chem. 2018, 14, 1961–1971, doi:10.3762/bjoc.14.171
- Materialforschung und -prüfung (BAM), Richard-Willstätter-Str. 11, 12489 Berlin, Germany Laboratory of Bioimaging and Pathology, UMR 7021 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 Route du Rhin, F-67401 Illkirch-Graffenstaden, France 10.3762/bjoc.14.171 Abstract We introduce herein boron
Pyrene–nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies
Beilstein J. Org. Chem. 2017, 13, 2521–2534, doi:10.3762/bjoc.13.249
- reporting pyrenyl group and hydrogen-bonding biological nucleobase vector to be tested in DNA recognition and bioimaging applications. Results and Discussion A straightforward, one-pot two-step methodology for aryl–nucleobases has been recently developed in our laboratory and was examined in respect to
- better to single-stranded T10 and double-stranded (dA)10-T10. Confocal microscopy Over the past years, there has been an increased interest in the development of luminescent probes for bioimaging. In that respect, both metal-containing [35] as well as organic [36] luminophores were examined. We found
Structure–property relationships and third-order nonlinearities in diketopyrrolopyrrole based D–π–A–π–D molecules
Beilstein J. Org. Chem. 2017, 13, 2374–2384, doi:10.3762/bjoc.13.235
- utilized in two-photon excited fluorescence microscopy and bioimaging [13][14], most often upon their further structural tuning towards higher polar character and solubility in water [20][21][22]. Their linking to porphyrins proved to be a useful strategy for two-photon photodynamic therapy [23][24][25
Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications
Beilstein J. Org. Chem. 2017, 13, 675–693, doi:10.3762/bjoc.13.67
- , chemical sensing, biosensing, bioimaging and nanomedicine, due to their unique tuneable photoluminescence (PL) properties, chemical inertness, high water solubility, ease and low cost fabrication and more importantly, low toxicity profiles. The latter makes these fluorescent nanomaterials attractive for a
- with blue emission have QYs that are not suitable for bioimaging applications. CDs with multicolour/excitation-dependent emission that can be red shifted and avoid the cellular autofluorescence window, are a good alternative. Unfortunately, the CD fluorescence tends to lose intensity upon red-shifting
- the excitation. An ideal CD probe for bioimaging applications will have either a high QY in the blue, or adequate green to red emission. Thus, the green-emissive glucose-based CDs produced by Wang et al. are ideal for this type of application and the team showed their applicability in cell
New synthetic strategies for xanthene-dye-appended cyclodextrins
Beilstein J. Org. Chem. 2016, 12, 537–548, doi:10.3762/bjoc.12.53
- bioimaging, while the mechanism behind the formation of the versatile, supramolecular assemblies deserves further investigation. Structures of fluorescent xanthene dyes. Rhodamine B·HCl 1 and fluorescein disodium salt 2. Reaction scheme for the synthesis of rhodamine-appended β-CD. TLC plates at different
Learning from the unexpected in life and DNA self-assembly
Beilstein J. Org. Chem. 2015, 11, 2713–2720, doi:10.3762/bjoc.11.292
- into who I was as a scientist, at least at that moment in my career. All of the project ideas that made the final cut involved using a combination of molecular recognition, self-assembly, and nucleic acids to build functional architectures for applications in biosensing or bioimaging (Figure 1). As my
- bioimaging. Adapted with permission from [3]. Copyright (2014) American Chemical Society. Adapted with permission from [4]. Copyright (2015) American Chemical Society. Split aptamers use molecular recognition to drive the assembly of two DNA strands. Placing reactive functional groups at the termini of the
Smart molecules for imaging, sensing and health (SMITH)
Beilstein J. Org. Chem. 2015, 11, 2540–2548, doi:10.3762/bjoc.11.274
- conjugated with targeting ligands, and bioimaging studies have shown that they enable fluorescence microscopy and mesoscale imaging of diverse biomedical targets such as tumors, infection, bone, cell death, and brown adipose tissue [37][38] (Figure 3). Several of these molecular probes are commercially
Impact of multivalent charge presentation on peptide–nanoparticle aggregation
Beilstein J. Org. Chem. 2015, 11, 792–803, doi:10.3762/bjoc.11.89
- controlled assembly of nanoparticles by means of biomolecules is crucial for biological and medical applications such as sensing [4], bioimaging [5], and medical diagnostics [6]. Although nanoparticles are also applied as targeted biomarkers and drug-delivery agents to tumor cells [7], only very little is
Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores
Beilstein J. Org. Chem. 2015, 11, 659–667, doi:10.3762/bjoc.11.74
- diverse analytes and in relevant biosensing and bioimaging applications [73]. One critical aspect for the evaluation of biological activities using fluorescent dyes (e.g., the deprotonated form of 4-methylumbelliferone) [74] is to determine their spectroscopic features in different environments (local pH
Multivalent glycosystems for nanoscience
Beilstein J. Org. Chem. 2014, 10, 2345–2347, doi:10.3762/bjoc.10.244
- the field of glycosciences. This enterprise has focused its research on the potential applications and social benefits that lie in the field. For instance, multivalent glycoconjugates can be used as anti-adhesive drugs against microbial infections. They could be developed into bioimaging agents that
Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions
Beilstein J. Org. Chem. 2014, 10, 2235–2242, doi:10.3762/bjoc.10.232
- Rebecca Faißt, Jessica Pfotzer, and Verena Goldbach for synthesis of cyclopropene derivatives and the Bioimaging Center of the University of Konstanz for providing the fluorescence microscopy instrumentation.
Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives
Beilstein J. Org. Chem. 2014, 10, 2175–2185, doi:10.3762/bjoc.10.225
- different interactions with DNA/RNA. Future prospects also include the synthesis of fluorescent DBTAA derivatives, which are expected to transfer observed intriguing DBTAA-DNA/RNA binding properties in a lower concentration range and broaden the set of DBTAA applications by cell-bioimaging. Such
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