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Search for "biosynthetic pathway" in Full Text gives 81 result(s) in Beilstein Journal of Organic Chemistry.
Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663
Beilstein J. Org. Chem. 2012, 8, 501–513, doi:10.3762/bjoc.8.57
- individual genes of this cluster for the biosynthetic pathway and for its regulation. The genes inactivated in this study are summarized in Table 1, and a complete list of the genes contained in the insert of cosmid ppzOS04 is given in Table S1 of Supporting Information File 1. Results and Discussion
Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla
Beilstein J. Org. Chem. 2012, 8, 283–289, doi:10.3762/bjoc.8.30
- indicates the involvement of a nonenzymatic step during their formation. A possible biosynthetic pathway to 5 and 6 (Scheme 2) could involve an oxidation at C4. This oxidation could proceed in a similar way to that required for the introduction of the 7-OH group in 7,8-di-HETE (3). A lipoxygenase-mediated
Novel fatty acid methyl esters from the actinomycete Micromonospora aurantiaca
Beilstein J. Org. Chem. 2011, 7, 1697–1712, doi:10.3762/bjoc.7.200
- counterparts 50 and 51 by dehydrogenation. A two-carbon elongation of 50 and 51 by means of the fatty acid biosynthetic pathway can generate 55 and 56, while their reduction to the respective alcohols provides 47 and 48. Acetoin (44) was also found as a major compound, together with its derivatives 3
Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes
Beilstein J. Org. Chem. 2011, 7, 1622–1635, doi:10.3762/bjoc.7.191
- ) will be mentioned. The list is divided into freshwater, marine and terrestrial biosyntheses and arranged chronologically according to the first description of the respective biosynthetic pathway. As cyanobacterial secondary metabolites frequently occur as classes of related molecules, only a single
- representative of each structural class will be discussed. NRPS and PKS pathways in freshwater cyanobacteria Microcystin The first biosynthetic pathway identified and partially characterized for cyanobacteria was the mixed NRPS/PKS pathway catalyzing the formation of the hepatotoxin microcystin 1 (Figure 3) in
- -10-phenyldeca-4,6-dienoic acid); more than 60 isoforms of the peptide have been described. The pentapeptide nodularin is structurally closely related and shares a highly similar biosynthetic pathway [20]. The biosynthetic assembly line of microcystin was predicted to start with the activation of
Advances in synthetic approach to and antifungal activity of triazoles
Beilstein J. Org. Chem. 2011, 7, 668–677, doi:10.3762/bjoc.7.79
- antifungal triazoles is due to differences or alterations in the composition of membrane associated sterols, alterations in the biosynthetic pathway of ergosterol, genetic changes in the enzyme by mutation, over expression, gene amplification etc. Secondary resistance has been observed by prolonged exposure
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
Beilstein J. Org. Chem. 2009, 5, No. 37, doi:10.3762/bjoc.5.37
- bacterium Streptomyces cattleya as part of its defense strategy since 4-fluorothreonine (2) has antibiotic activity and fluoroacetate (1) is a toxin [1]. The biosynthetic pathway from fluoride ion to these fluorometabolites has largely been elucidated and is summarised in Scheme 1 [2]. The first committed
- 10 and 11. X-Ray crystal structure of cyclohexylammonium salt 8a. Biosynthetic pathway from fluoride ion to fluoroacetate 1 and 4-fluorothreonine 2 in S. cattleya [2]. Synthetic route A. Reagents and conditions: a) acetone, concd H2SO4 (cat.), 6 h, 86%; b) Deoxo-fluor™, DCM, 40 °C, 30 min, 84%; c
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