Total synthesis of (±)-coerulescine and (±)-horsfiline

• Mukund G. Kulkarni,
• Attrimuni P. Dhondge,
• Sanjay W. Chavhan,
• Ajit S. Borhade,
• Yunnus B. Shaikh,
• Deekshaputra R. Birhade,
• Mayur P. Desai and
• Nagorao R. Dhatrak

Beilstein J. Org. Chem. 2010, 6, 876–879, doi:10.3762/bjoc.6.103

• against human breast cancer cells. This work led to intense interest in the total synthesis of these alkaloids and their derivatives. Despite previous intensive studies, the total synthesis of coerulescine (1) and horsfiline (2) remain attractive targets for demonstrating the efficacy of newer synthetic

Studies on polynuclear furoquinones. Part 1: Synthesis of tri- and tetra- cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids

• Faruk H. Shaik and
• Gandhi K. Kar

Beilstein J. Org. Chem. 2009, 5, No. 47, doi:10.3762/bjoc.5.47

• viral hepatitis, cardiac and vascular disorder, hypertension, miscarriage and menstrual disorder [3][9] etc. It has been reported to show potential anticancer activity [10] (against human breast cancer), cytotoxic and antiplatelet aggregation activities [1][11]. It also acts as an antibacterial [1

Recent progress on the total synthesis of acetogenins from Annonaceae

• Nianguang Li,
• Zhihao Shi,
• Yuping Tang,
• Jianwei Chen and
• Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

• 232, which has served as an intermediate in a total synthesis of uvaricin (225). Total synthesis of trilobin Trilobin (233), which was isolated from the the bark of Asimina triloba by McLaughlin’s group [71] in 1992, has high potency against human lung cancer, breast cancer, and colon cancer cell

Transition- metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction

• Sarbani Pal,
• Mohammad Ashrafuddin Khan,
• P. Bindu and
• P. K. Dubey

Beilstein J. Org. Chem. 2007, 3, No. 35, doi:10.1186/1860-5397-3-35

• lipids while displaying potent estrogen antagonist properties in the breast and uterus. A most common example of SERM is tamoxifen which has been the therapy of choice in the endocrine treatment of all stages of hormone-dependent breast cancer and in the primary and secondary chemoprevention of breast

• cancer. Recently, raloxifene showed promising results in clinical trial and is expected to provide an alternative to current hormone replacement therapy (HRT) that has been causally linked to breast cancer.[2] Another compound B (Figure 1) was identified as a thrombin inhibitor that could be utilized in

Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells

• Li-Rong Sun,
• Chen Qing,
• Yan-Li Zhang,
• Shu-Yu Jia,
• Zhong-Rong Li,
• Shen-Ji Pei,
• Ming-Hua Qiu,
• Michael L. Gross and
• Samuel X. Qiu

Beilstein J. Org. Chem. 2007, 3, No. 3, doi:10.1186/1860-5397-3-3

• cytotoxicity against rat EAC (Ehrlich ascites carcinoma) and MDA-MB-A231 (human breast cancer) cells with IC50 values of 0.52 and 6.74 μM for 1, and 0.19 and 10.21 μM for 2, suggesting their potential for further investigation as anti-cancer agents. 1. Background Black cohosh (Cimicifuga racemosa (L.) Nutt

• significant cytotoxicity against the rat EAC tumor cell line with IC50 values of 0.35 and 0.14 μg/ml for 1 and 2, respectively. Both 1 and 2 also demonstrated moderate inhibition to human MDA-MB-A231 breast cancer cell. While other compounds were shown to be devoid of significant cytotoxicity, implying the

• the potential for further examination of the cycloartane triterpene glycosides from Cimicifuga for the prevention or treatment of human cancers, especially for breast cancer. It should be noted that the extracts of Cimicifuga are currently widely available for sale as a dietary supplements used for