Beilstein J. Org. Chem.2026,22, 455–460, doi:10.3762/bjoc.22.33
isomeric benzo[c]acridine. The structural reassignment of compound 968 will aid the medicinal chemistry development of this important compound.
Keywords: cancermetabolism; compound 968; glutaminase; Introduction
Cancer cells often show a strong reliance on glutamine uptake and metabolism [1][2
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Graphical Abstract
Figure 1:
The glutaminase enzymes GLS1 and GLS2 catalyze the hydrolysis of glutamine to glutamate and ammonia...
Beilstein J. Org. Chem.2017,13, 239–246, doi:10.3762/bjoc.13.26
Ananda Herath Nicholas D. P. Cosford CancerMetabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA 10.3762/bjoc.13.26 Abstract A versatile continuous-flow synthesis of highly functionalized 1,2,4
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Graphical Abstract
Scheme 1:
In-flask (batch) preparation of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles (S1P1 agonists) [27].