Beilstein J. Org. Chem.2010,6, No. 20, doi:10.3762/bjoc.6.20
thiourea, urea and guanidine. In this review we summarise the advances over the last decade in the synthesis of oligosaccharide mimetics that possess amide and pseudoamide linkages, as well as studies focussing on their supramolecular and recognition properties.
Keywords: carbopeptoids; glycoclusters
years, some reviews on SAAs have summarised the different synthetic methods used to obtain such molecules [12][13][14] as well as their applications to access to a diversity of linear, branched and cyclic pseudooligosaccharides and glycomimetics often referred to as carbopeptoids [13][14][15][16][17
: carbopeptoids
The replacement of the glycosidic oxygen atom by an amide group leads to amide-linked sugars (Figure 1), which are synthesised by the sequential coupling of SAAs to form a class of compounds commonly referred to as carbopeptoids. The use of the amide functional group to connect sugar building
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Graphical Abstract
Figure 1:
Schematic representation of sugar aminoacids (SAAs) and (pseudo)amide oligosaccharide mimetics.