Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.

• Birthe Sandargo,
• Leon Kaysan,
• Rémy B. Teponno,
• Christian Richter,
• Benjarong Thongbai,
• Frank Surup and
• Marc Stadler

Beilstein J. Org. Chem. 2021, 17, 1385–1391, doi:10.3762/bjoc.17.97

• , Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon, Institute of Microbiology, Technical University of Braunschweig, Germany 10.3762/bjoc.17.97 Abstract A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane

• : antibiotics; Basidiomycota; carotane; fulvoferruginin; Marasmius; sesquiterpenoid; Introduction The family Marasmiaceae (Agaricomycetes, Basidiomycota) presently contains ten genera with Marasmius Fr. being the predominant one (currently comprising over 600 recognized species). Most of these fungi are

• Marasmius spp. include the cryptoporic acids [4], marasmals, marasmones, and oreadones [5][6], the caryophyllane hebelophyllene C [7], and the carotane fulvoferruginin (1) [8] (Figure 1). The latter is the only known secondary metabolite from M. fulvoferrugineus Gilliam and displays a modest antibiotic and