Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• . Three different approaches to such reaction systems are presented herein and discussed in view of their advantages and disadvantages as well as trends for their future development. Keywords: biocatalysis; chemo-enzymatic reaction sequences; continuous flow; coupled reactions; reaction cascades

• become reality: In the last few decades the concept of reaction cascades has become increasingly popular and has been proven to be a viable synthetic route to many classes of organic compounds [13][14][15]. Biotransformations consisting of coupled sequential and/or parallel reactions catalyzed by one or

• cascades catalyzed by a single enzyme belong instead to the first-generation processes. When following the logic of the chosen classification of enzymatic processes, the final or fourth-generation biotransformations would be defined as coupled chemo(enzymatic) reactions in continuous-flow systems based on

Recent advances in the gold-catalyzed additions to C–C multiple bonds

• He Huang,
• Yu Zhou and
• Hong Liu

Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103

• cycloisomerization to produce pyrrolo/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones 330 [161], pyrrolo/pyrido[2,1-a][1,3]benzoxazinones 332 [162], benzo[e]indolo[1,2-a]-pyrrolo[2,1-c][1,4]diazepine-3,9-diones 335 [163], and fused quinoxalinones 337 [164]. These cascades are proposed to occur from an initial enol lactone

• ]. From the discovery and development of metal–carbenoids in cycloadditions with alkenes, as well as the internal redox reactions on alkynes, a further extensive investigation was focused on the new redox/cycloaddition cascades on alkynes to obtain azacyclic compounds 363 [171]. The central cores of the

Synthetic applications of gold-catalyzed ring expansions

• David Garayalde and
• Cristina Nevado

Beilstein J. Org. Chem. 2011, 7, 767–780, doi:10.3762/bjoc.7.87

• -catalyzed synthesis of ventricos-7(13)-ene. 1,2- vs 1,3-Carboxylate migration. Gold-catalyzed cycloisomerization of vinyl alkynyl cyclopropanes. Proposed mechanism for the cycloisomerization of vinyl alkynyl cyclopropanes. Gold-catalyzed 1,2-acyloxy rearrangement/cyclopropanation/cycloisomerization cascades

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• species can lead to an overall 1,2-aryl (neophyl) migration [20]. We have previously communicated our initial findings in the application of tandem radical cascades toward the 2-aza-5,6-benzonorbornenyl system [21]. We now present our wider investigations of this system and its synthetic utility. Results