Synthesis and anti-cancer activity of naphthalimide–organylselanyl conjugates

• Rajkumar Ravi and
• Selvakumar Karuthapandi

Beilstein J. Org. Chem. 2026, 22, 416–435, doi:10.3762/bjoc.22.29

• epidermal growth factor receptor (EGFR) in which erlotinib, a well-known anticancer drug, binds. Keywords: cell line study; density functional theory; MDA-MB-231; molecular docking; organoselanyl conjugates; Introduction Cancer remains one of the most common and life-threatening diseases globally, posing

• , which confirms similar types of non-covalent interactions. Altogether, the in-vitro cell line study and the molecular docking simulation showed that the compounds 7 and 8 have considerable anticancer activity against the breast cancer cell line of MDA-MB-231. Overall, this study provides valuable