Beilstein J. Org. Chem.2006,2, No. 15, doi:10.1186/1860-5397-2-15
]. For these kind of substrates, catalysts based on Ni, Pd, and Pt have been used, and further efforts are directed toward improving the chemoselectivity and regioselectivity of this ring-opening reaction. [18][19]
We now demonstrate that aryl aldehydes and ketones as well as aryl epoxides can also
Beilstein J. Org. Chem.2005,1, No. 7, doi:10.1186/1860-5397-1-7
the cyclodehydration reactions of diol substrates were complicated by selectivity and reactivity issues (Figure 1 and Figure 2), we turned to an alternative strategy which would not rely on chemoselectivity in the cyclodehydration step. To this end, mesylates 11 were synthesized (Scheme 3).
Treatment