Total synthesis of panicein A₂

• Lili Yeung,
• Lisa I. Pilkington,
• Melissa M. Cadelis,
• Brent R. Copp and
• David Barker

Beilstein J. Org. Chem. 2015, 11, 1991–1996, doi:10.3762/bjoc.11.215

• cytotoxicity against a number of tumour cell lines. Keywords: modified Claisen rearrangement; sesquiterpene; chromenol; total synthesis; Introduction The panicein family is an unusual family of natural products, which generally consist of an aromatic sesquiterpene group linked to a quinone (as seen in

• panicein A (1), Figure 1), hydroquinone moiety (as seen in paniceins D (2), F (3) and F1 (4)) or chromenol as seen in panicein A2 (5). The first members of the panicein family were isolated by Cimino et al. in 1973 from the marine sponge Halichondria panacea [1]; members of this family have since been