Synthesis of new triazole- based trifluoromethyl scaffolds

• Michela Martinelli,
• Thierry Milcent,
• Sandrine Ongeri and
• Benoit Crousse

Beilstein J. Org. Chem. 2008, 4, No. 19, doi:10.3762/bjoc.4.19

• scaffolds. Keywords: copper; catalysis; fluorine; heterocycle; click chemistry; peptidomimetics; Background The 1,2,3-triazole system has widespread uses, and it has been considered as an interesting component in terms of biological activity [1][2][3][4][5]. Although the use of heterocyclic moieties in

• ]. The copper(I)-catalyzed 1,3-dipolar cycloaddition [33][34][35][36][37][38] of organic azides and alkynes (also called “click chemistry”) resulting in the formation of 1,2,3-triazoles has become an increasingly attractive area [39]. According to the literature [33][34][35][36][37][38], the Cu(I