Beilstein J. Org. Chem.2011,7, 29–33, doi:10.3762/bjoc.7.5
)-impurity 21 (Scheme 4). The catalytic hydrogenation of indole 19 proved to be a difficult reaction as significant formation of the dehalogenated products was observed, repeated recrystallization from MeOH afforded pure indole 20.
Since dehalogenation was observed during the platinum oxide reduction of the
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Graphical Abstract
Figure 1:
Sertindole (1), process related impurities and metabolites.
Beilstein J. Org. Chem.2007,3, No. 46, doi:10.1186/1860-5397-3-46
corresponding alkanes with good to excellent yields. Such a process complies with the long-standing pursuit of an environmentally acceptable process for desulfurisation, dehalogenation or deoxygenation that operates under mild reaction conditions. In this context, special attention must be paid to a paper
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Graphical Abstract
Figure 1:
Xanthates 1a, 2a and their corresponding alkanes.