Activation of pentafluoropropane isomers at a nanoscopic aluminum chlorofluoride: hydrodefluorination versus dehydrofluorination

• Maëva-Charlotte Kervarec,
• Thomas Braun,
• Mike Ahrens and
• Erhard Kemnitz

Beilstein J. Org. Chem. 2020, 16, 2623–2635, doi:10.3762/bjoc.16.213

• such as hydrodefluorinations and dehydrofluorinations were observed, followed by hydroarylation and Friedel–Crafts-type reactions under mild conditions. Keywords: aluminum fluoride; C–F bond activation; dehydrofluorination; hydrodefluorination; hydrofluorocarbons; Introduction Hydrofluorocarbons

• acidic centers can induce dehydrofluorination reactions, involving the abstraction of a fluoride ion by heterolytic bond cleavage [28][29][30][31]. AlF3-based catalysts are among the strongest Lewis acidic materials. They exhibit an effective activity in C–F bond conversion reactions and are widely

• with germane, dehydrofluorination products were detected. Besides, 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb) was as well effectively activated at ACF to yield the corresponding dehydrofluorination product 2-chloro-3,3,3-trifluoropropene (HFO-1233xf) without the use of any additional hydrogen

Synthesis and in vitro cytotoxicity of acetylated 3-fluoro, 4-fluoro and 3,4-difluoro analogs of D-glucosamine and D-galactosamine

• Štěpán Horník,
• Lucie Červenková Šťastná,
• Petra Cuřínová,
• Jan Sýkora,
• Kateřina Káňová,
• Roman Hrstka,
• Ivana Císařová,
• Martin Dračínský and
• Jindřich Karban

Beilstein J. Org. Chem. 2016, 12, 750–759, doi:10.3762/bjoc.12.75

• dehydrofluorination of 51 to enal 52 which then added piperidine to give 53 as a byproduct (Scheme 6). To avoid the action of basic amines, a silica gel mediated anomeric deacetylation, recommended for 2-aminosugars [61], was tried. The reaction proceeded extremely slowly with our substrate 6 and the product 51 was

Photorelease of phosphates: Mild methods for protecting phosphate derivatives

• Sanjeewa N. Senadheera,
• Abraham L. Yousef and
• Richard S. Givens

Beilstein J. Org. Chem. 2014, 10, 2038–2054, doi:10.3762/bjoc.10.212

• the lack of product formation for 2-hydroxy-6-trifluoromethylnaphthylene photo-dehydrofluorination reported by Seiler and Wirz [51]. For the 1,5-HNA acetate, the less reactive (higher pKa) of the leaving OAc group of 27 vs DEP, fluorescence decay and reversible ESIPT processes are major factors