Beilstein J. Org. Chem.2023,19, 1511–1524, doi:10.3762/bjoc.19.108
smoothly to the dihydroberberine in the absence of the copper salt [37]. This suggests the Cu2+ may be involved in aiding in the air-oxidation to the fully aromatic berberine core. The prime benefit of the route shown in Scheme 1 is the ease of introducing structural variability, as the precursor is easily
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Graphical Abstract
Figure 1:
Zones of inhibition for 1 mg of evaporated methanolic (MeOH) extracts from various parts of the A. ...
Beilstein J. Org. Chem.2020,16, 1606–1616, doi:10.3762/bjoc.16.133
Molecular Biology, Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Via Saffi 2, 61029 Urbino, Italy 10.3762/bjoc.16.133 Abstract Dihydroberberine (DHBER), the partially reduced form of the alkaloid berberine (BER), is known to exhibit important biological activities. Despite this fact
arylhydrazono-DHBERs and -THBERs has been evaluated on NCI-H1975 lung cancer cells.
Keywords: antiproliferative agent; dihydroberberine; hydrazones; reduction; tetrahydroberberine; Introduction
The rhizome of Coptis chinensis Franch. is a common remedy in traditional oriental medicine for the treatment of
activity [13][14][15][16][17][18][19], and an increased DNA and RNA binding efficacy [4][6][9], due to its aromatic interactions with the biological macromolecules [20].
Another interesting and promising derivative is dihydroberberine (DHBER), the reduced form of BER. The enaminic function of this alkaloid
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Graphical Abstract
Scheme 1:
Preparation of functionalized-BER, -DHBER and -THBER derivatives.