Azide–alkyne cycloaddition (click) reaction in biomass-derived solvent Cyrene^TM under one-pot conditions

• Zoltán Medgyesi and
• László T. Mika

Beilstein J. Org. Chem. 2025, 21, 1544–1551, doi:10.3762/bjoc.21.117

• for 4 consecutive runs, which resulted in high conversion of 1a in each run (Figure 6). To evaluate and compare the one-pot protocol with published methods, the environmental factor (E-factor) was calculated for the synthesis of 3a. Considering an average 88% solvent recovery, the E-factor is 76. It

The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography

• Freddy Pessel,
• Jacques Augé,
• Isabelle Billault and
• Marie-Christine Scherrmann

Beilstein J. Org. Chem. 2016, 12, 2351–2357, doi:10.3762/bjoc.12.228

• approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography. Keywords: environmental factor; flash chromatography; green metrics; mass intensity; purification; Introduction As part of a more respectful environmental

• on the environmental factor E of a process seems pretty obvious, we have developed here a tool to quantify it. In an extremely favourable case with a 95% pure sample (x = 0.95), a very easy separation achievable with a small mass of silica (A = 10) and Rf = 0.35, we find, for low density eluent (0.6

EcoScale, a semi- quantitative tool to select an organic preparation based on economical and ecological parameters

• Koen Van Aken,
• Lucjan Strekowski and
• Luc Patiny

Beilstein J. Org. Chem. 2006, 2, No. 3, doi:10.1186/1860-5397-2-3

• use of this parameter is to adapt reaction sequences in a way that transformations with low atom economy are limited to a minimum. Environmental factor (E-factor) [5][6][7][8] This factor is the ratio of the weight of generated waste to the total weight of the end product. It is a useful tool for