Creating molecular macrocycles for anion recognition

• Amar H. Flood

Beilstein J. Org. Chem. 2016, 12, 611–627, doi:10.3762/bjoc.12.60

• ]. Starting with an on–off binding and release ratio of about 10 with foldamer 23 [46], and, by using secondary contacts often seen in biology, we have reached up to a ratio of 84 with 25 [47]. We also saw protein-like driving forces elicit unprecedented Cl− binding in semi-aqueous solutions (50:50 water

• /acetonitrile). The aryl-triazole foldamer 24 formed a double helix with overall stability of β2 = 1012 M−2 [48]. Importantly, while we observed clear penalties to the binding affinity when we added extra water, we also saw that extra water increases the stability of the duplex. The analogy to hydrophobic

Supramolecular chemistry: from aromatic foldamers to solution-phase supramolecular organic frameworks

• Zhan-Ting Li

Beilstein J. Org. Chem. 2015, 11, 2057–2071, doi:10.3762/bjoc.11.222

• cavity of cucurbit[8]uril (CB[8]) are highlighted. Keywords: donor–acceptor interaction; foldamer; hydrogen bond; radical cation dimerization; supramolecular organic framework; Review Childhood and growing up I was born on July 23rd, 1966 in the small, remote village of Fang-Liu (a combination of two

• exhibit similar reactivity. These observations suggested that the folded conformation, such as in 23, promoted the hydrolysis of the anisole, which we ascribed to the complexation of the foldamer to Li+ cation (Scheme 11). We proposed that this complexation increased the efficient concentration of the OH

• molecule to give rise to foldamer-derived dynamic rotaxanes [54]. Aromatic hydrazide foldamers: Aromatic hydrazides have a high propensity towards co-planarity [55][56]. Nowick introduced this unit into peptide backbones to increase the stability of artificial β-sheets [55]. Junli hoped to extend the

meta-Oligoazobiphenyls – synthesis via site-selective Mills reaction and photochemical properties

• Raphael Reuter and
• Hermann A. Wegner

Beilstein J. Org. Chem. 2012, 8, 877–883, doi:10.3762/bjoc.8.99

• revealed that the overall degree of switching was independent of the connected azo-units. However, one of the azobonds in the bis-azobiphenyl is isomerized preferentially despite the high structural similarity. Keywords: azobenzene; cross-coupling reaction; foldamer; molecular switches; photochromism

Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique

• Raheleh Rezaei Araghi,
• Carsten C. Mahrenholz,
• Rudolf Volkmer and
• Beate Koksch

Beilstein J. Org. Chem. 2012, 8, 640–649, doi:10.3762/bjoc.8.71

• denaturation. Keywords: β- and γ-amino acids; coiled coil; foldamer; screening libraries; SPOT technique; Introduction Coiled-coil domains, which consist of two or more α-helices, are the most common representatives of α-helix-mediated protein–protein interactions, which regulate many important biological

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

• José L. Jiménez Blanco,
• Fernando Ortega-Caballero,
• Carmen Ortiz Mellet and
• José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

• methods [38][44] and infrared ion-dip spectroscopy [45] in order to interpret the data from CD, IR and NMR experiments reliably. To complement its research programme on foldamer design and because of the absence of structural investigations on linear homo-oligomers constrained by 4-membered rings, Fleet