Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

• Thilo Focken and
• Stephen Hanessian

Beilstein J. Org. Chem. 2014, 10, 1848–1877, doi:10.3762/bjoc.10.195

• in fragrances (Scheme 18). Hailes and co-workers were interested in developing a short synthetic route to both enantiomers of methyl jasmonate and methyl dihydrojasmonate, respectively [48]. To this end, they investigated the conjugate addition of chiral 2-propenylphosphonamides such as 64a, derived

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• many essential oils and fragrances with a boiling point of 198 °C, was encapsulated in different types of nanosponges as a liquid oil model [43]. β-CD-1/4 nanosponges can incorporate 8% w/w of linalool within their structure. The entrapment of linalool in the nanosponge matrix was confirmed by DSC

Flow photochemistry: Old light through new windows

• Jonathan P. Knowles,
• Luke D. Elliott and
• Kevin I. Booker-Milburn

Beilstein J. Org. Chem. 2012, 8, 2025–2052, doi:10.3762/bjoc.8.229

• employed in the synthesis of a range of compounds of commercial interest including fragrances and pharmaceuticals. One major disadvantage of using this reaction on a large scale is the potential for fires or detonation of accumulating peroxide products. Other disadvantages include inefficient irradiation

Palladium-catalyzed C–N and C–O bond formation of N-substituted 4-bromo-7-azaindoles with amides, amines, amino acid esters and phenols

• Rajendra Surasani,
• Dipak Kalita,
• A. V. Dhanunjaya Rao and
• K. B. Chandrasekhar

Beilstein J. Org. Chem. 2012, 8, 2004–2018, doi:10.3762/bjoc.8.227

• compounds, pharmaceuticals, fragrances, cosmetics and polymers [11][12][13][14][15][16][17]. Among others Buchwald, Hartwing and co-workers followed by many other groups during the past decade reported the metal-catalyzed formation of carbon–heteroatom bonds [18][19][20][21][22][23][24][25][26][27][28][29

Alkoxide-induced ring opening of bicyclic 2-vinylcyclobutanones: A convenient synthesis of 2-vinyl-substituted 3-cycloalkene-1-carboxylic acid esters

• Xiufang Ji,
• Zhiming Li,
• Quanrui Wang and
• Andreas Goeke

Beilstein J. Org. Chem. 2012, 8, 650–657, doi:10.3762/bjoc.8.72

• Xiufang Ji Zhiming Li Quanrui Wang Andreas Goeke Department of Chemistry, Fudan University, 220 Handan Road, 200433 Shanghai, P. R. China Shanghai Givaudan Ltd., Fragrances, 298 Li Shi Zhen Road, 201203 Shanghai, P. R. China 10.3762/bjoc.8.72 Abstract The fused 2-vinyl or 2-phenyl substituted

Development of dynamic kinetic resolution on large scale for (±)-1-phenylethylamine

• Lisa K. Thalén and
• Jan-E. Bäckvall

Beilstein J. Org. Chem. 2010, 6, 823–829, doi:10.3762/bjoc.6.97

• donor. Keywords: dynamic kinetic resolution; kinetic resolution; racemization; Shvo; Candida antartica lipase B; Introduction Chiral amines are important building blocks in the synthesis of many pharmaceuticals, fragrances, and agricultural products, and it is therefore important to develop methods