Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

• Alemayehu Gashaw Woldegiorgis and
• Xufeng Lin

Beilstein J. Org. Chem. 2021, 17, 2729–2764, doi:10.3762/bjoc.17.185

• ., fredericamycin A and acutumine [99]), SPINOL-based ligands and catalysts [100], and organometallic complexes with important applications. The use of chiral catalysts for spirocyclization reactions brings asymmetry at the site of the spirocyclic center while tolerating different electronic and steric functional

Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

• Charles Dylan Turner and
• Marco A. Ciufolini

Beilstein J. Org. Chem. 2011, 7, 1475–1485, doi:10.3762/bjoc.7.171

• activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits. Keywords: alkaloids; directed aromatic functionalization; fredericamycin; heterocyclic compounds; lithiation

• specific synthetic endeavors in our group. Herein, we illustrate the application of such techniques to three representative problems that we have addressed over the years: The syntheses of fredericamycin A, nothapodytine B, and topopyrones B and D. Fredericamycin A This initial portion of the present

• review recounts the first project that the senior author of this paper launched as an independent academic in 1984. A structurally novel natural product by the name of fredericamycin A (1, Scheme 1) had been discovered only two years prior and determined to be strongly cytotoxic [1][2][3][4][5]: A