Beilstein J. Org. Chem.2021,17, 1385–1391, doi:10.3762/bjoc.17.97
antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
Keywords
: antibiotics; Basidiomycota; carotane; fulvoferruginin; Marasmius; sesquiterpenoid; Introduction
The family Marasmiaceae (Agaricomycetes, Basidiomycota) presently contains ten genera with Marasmius Fr. being the predominant one (currently comprising over 600 recognized species). Most of these fungi are
Marasmius spp. include the cryptoporic acids [4], marasmals, marasmones, and oreadones [5][6], the caryophyllane hebelophyllene C [7], and the carotane fulvoferruginin (1) [8] (Figure 1). The latter is the only known secondary metabolite from M. fulvoferrugineus Gilliam and displays a modest antibiotic and
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Graphical Abstract
Figure 1:
Structures of fulvoferruginin (1) and the newly isolated derivatives fulvoferruginins B–F (2–6).