A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis

• Theodore Groth,
• Rudiyanto Gunawan and
• Sriram Neelamegham

Beilstein J. Org. Chem. 2021, 17, 1712–1724, doi:10.3762/bjoc.17.119

• -3GalNAcT (B3GALNT1) to form the P antigen. The P1 antigen, on the other hand, is formed by the sequential action of β1-3GlcNAcT (B3GNT5), β1-4GalT (B4GALT1-6), and α1-4GalT (A4GALT) on the glycolipid core. 3) Gangliosides: This pathway encompasses all glycogenes responsible for synthesizing a/b/c

• gangliosides. UGCG is included to consider the addition of glucose to ceramide. ST3GAL5 and ST8SIA enzymes are added to take the core ganglioside structures to the a, b, and c levels. B4GALTs and B4GALNT1 are included to account for ganglioside elongation. Decoration of the gangliosides with sialic acid occurs

Simulating the enzymes of ganglioside biosynthesis with Glycologue

• Andrew G. McDonald and
• Gavin P. Davey

Beilstein J. Org. Chem. 2021, 17, 739–748, doi:10.3762/bjoc.17.64

• Andrew G. McDonald Gavin P. Davey School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland 10.3762/bjoc.17.64 Abstract Gangliosides are an important class of sialylated glycosphingolipids linked to ceramide that are a component of the mammalian cell surface, especially

• those of the central nervous system, where they function in intercellular recognition and communication. We describe an in silico method for determining the metabolic pathways leading to the most common gangliosides, based on the known enzymes of their biosynthesis. A network of 41 glycolipids is

• ganglioside biosynthesis, and altered ganglioside status in cancer, and the effects on network structure are predicted. The simulator is available at the Glycologue website, https://glycologue.org/. Keywords: gangliosides; Glycologue; glycosyltransferases; neuropathy; Svennerholm nomenclature; Introduction

SnCl₄-catalyzed solvent-free acetolysis of 2,7-anhydrosialic acid derivatives

• Kesatebrhan Haile Asressu and
• Cheng-Chung Wang

Beilstein J. Org. Chem. 2019, 15, 2990–2999, doi:10.3762/bjoc.15.295

• gangliosides and other Neu5Ac-containing glycans after its 2,7-anhydro backbone has been opened. Representative structures of bacterial glycans containing sialic acid, which can be chemically synthesized from sialyl donors, are illustrated in Figure 1 [2][3][4][5][22][23][24]. One way to obtain Neu5Ac

Preactivation-based chemoselective glycosylations: A powerful strategy for oligosaccharide assembly

• Weizhun Yang,
• Bo Yang,
• Sherif Ramadan and
• Xuefei Huang

Beilstein J. Org. Chem. 2017, 13, 2094–2114, doi:10.3762/bjoc.13.207

• glycolipid family including LewisX pentasaccharide 117, dimeric LewisX 118 [63], tristearoyl lipomannan 119 [64], gangliosides GM1 120 [65] and GM2 121 (Figure 5) [66], microbial glycans such as the heptasaccharide repeating unit of type V group B Streptococcus capsular polysaccharide 122 [67], β-glucan

Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

• Serge Pérez and
• Daniele de Sanctis

Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114

• constitution and dynamics of plasma membranes, the structural and physicochemical features of gangliosides have been somehow neglected presumably because of the lack of appropriate experimental techniques. X-ray reflectometry is a surface-sensitive analytical technique based on the measure of the intensity of

• biomimetic plasma membrane incorporating glycolipid rafts. The in situ chemical conversion of GD1a gangloside into its metabolic product under the action of sialidase was investigated. The outcome of the sialidase action is not limited to the creation of GM1 and AsialoGM1 gangliosides as it is accompanied by