Beilstein J. Org. Chem.2014,10, 1433–1444, doi:10.3762/bjoc.10.147
yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host–pathogen interactions in protozoal, bacterial
-carbohydrates, in particular multiarm PEGylation, is presented.
Keywords: bioavailability; carbohydrates; conjugates; glycoPEGylation; multivalent glycosystems; multivalent PEGylation; Introduction
In recent years, the modification of biotherapeutics by covalent conjugation with polyethyleneglycol (PEG) known
interaction with the target site.
GlycoPEGylation of proteins
PEGylation of proteins is usually performed on the ε-amine group of lysine or on the unprotected α-amino of the N-terminal amino acid using N-hydroxysuccinimidyl (NHS) activated PEGs or aldehyde PEGs. This conjugation leads to heterogeneous
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Graphical Abstract
Figure 1:
Types of PEG utilized for derivatization of drugs and peptides.