Beilstein J. Org. Chem.2021,17, 2726–2728, doi:10.3762/bjoc.17.184
] suggests a new concept of glycoblocks, which are subunits of 3D glycan structures. This concept may become useful in describing specific epitopes and functional units of glycans. With the recent pandemic experience, the need for glycobioinformatics for global health was highlighted, where the laboratory of
Beilstein J. Org. Chem.2020,16, 2046–2056, doi:10.3762/bjoc.16.171
monosaccharides. We define these “glycoblocks” as self-contained 3D units, uniquely identified by the nature of the residues they comprise, their linkages and structural/dynamic features. This alternative description of glycans’ 3D architecture can potentially lead to an easier prediction of sequence-to-structure
relationships in complex carbohydrates, with important implications in glycoengineering design.
Keywords: complex carbohydrates; fucose; glycoblocks; molecular dynamics; molecular recognition; N-glycans; xylose; Introduction
Complex carbohydrates (or glycans) are an essential class of biomolecules, directly
different N-glycoforms can be represented as a combination of spatial self-contained units, named “glycoblocks”, rather than in terms of monosaccharides and linkages. We find that this approach helps our understanding of N-glycans architecture in terms of equilibrium structures and relative populations and
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Graphical Abstract
Figure 1:
Representative structures of the plant N-glycans studied in this work with corresponding nomenclatu...