Beilstein J. Org. Chem.2011,7, 596–600, doi:10.3762/bjoc.7.69
desired product was observed in the absence of a goldcatalyst (entry 10).
With the optimized reaction conditions established (Table 1, entry 8), the scope of this chemistry was studied. As shown in Table 2, remote functional groups were readily tolerated. For example, good yields were obtained in the
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Graphical Abstract
Scheme 1:
Gold-catalyzed intermolecular oxidation of alkynes and allenes.
Beilstein J. Org. Chem.2011,7, 570–577, doi:10.3762/bjoc.7.66
encouraging results. Other gold catalysts and solvents were screened, with the best results being achieved with a higher catalyst loading of gold(I) chloride in methanol (Table 1, entry 10). The need for higher catalyst loading is tentatively ascribed to some form of instability of the goldcatalyst in