Beilstein J. Org. Chem.2016,12, 253–259, doi:10.3762/bjoc.12.27
-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained in good yield and diastereoselectivity. The
one-pot cascade quadruple protocol features readily available starting materials, simple manipulation, mild conditions and good atom economy.
Keywords: bifunctional catalysis; hexahydroisoindolinones; one-pot synthesis; quadruple cascade; Introduction
Isoindolines and their congeners are one kind of
is a frontier in organic synthesis.
However, compared with the synthesis of their congeners, the synthesis of fully-substituted hexahydroisoindolinones is much more difficult due to the steric hindrance and the high strain of the molecular architectures [17]. Three methods to synthesize 3-substituted