Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

• Zhongwei Hua,
• Nan Liu and
• Xiaohui Yan

Beilstein J. Org. Chem. 2024, 20, 741–752, doi:10.3762/bjoc.20.68

• expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) [11]. Crocins can also regulate the Nrf2 signaling pathway to protect the brain, liver, and other organs and decrease the expression of pro-inflammatory factors, such as TNF-α, prostaglandin E2 (PGE2), interleukin-1β (IL-1β

Correction: Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

• Yuan-Nan Yuan,
• Jin-Qiang Li,
• Hong-Bin Fang,
• Shao-Jun Xing,
• Yong-Ming Yan and
• Yong-Xian Cheng

Beilstein J. Org. Chem. 2023, 19, 1370–1371, doi:10.3762/bjoc.19.97

• , Shenzhen University, Shenzhen 518060, PR China Department of Pathogen Biology, Health Science Center, Shenzhen University, Shenzhen 518060, PR China 10.3762/bjoc.19.97 Keywords: arthropod; iNOS; Kronopolites svenhedini (Verhoeff); non-peptide small molecules; The structure of compound 1 of the original

Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

• Yuan-Nan Yuan,
• Jin-Qiang Li,
• Hong-Bin Fang,
• Shao-Jun Xing,
• Yong-Ming Yan and
• Yong-Xian Cheng

Beilstein J. Org. Chem. 2023, 19, 789–799, doi:10.3762/bjoc.19.59

• methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells. Keywords: arthropod; iNOS; Kronopolites svenhedini (Verhoeff); non-peptide small molecules; Introduction The millipede (class

• (1), kronopoiols A (2) and B (3), 5-O-methyldaphnegiralin C1 (4), and kronoponoids A (7) and B (8). Biological activity experiments were conducted with the isolated compounds, revealing that compounds 3–5 exhibited the expression of iNOS in a dose-dependent manner. Results and Discussion Structural

• compounds, cytotoxic and anti-inflammatory properties were evaluated. In particular, a mouse pancreatic cancer cell line (Panc02-h7-GP-GFP) was used to determine cytotoxicity. Additionally, LPS-induced pro-inflammatory expression of iNOS and COX-2 in RAW264.7 cells was evaluated. Antitumor activity of

Microwave-assisted cyclizations promoted by polyphosphoric acid esters: a general method for 1-aryl-2-iminoazacycloalkanes

• Jimena E. Díaz,
• María C. Mollo and
• Liliana R. Orelli

Beilstein J. Org. Chem. 2016, 12, 2026–2031, doi:10.3762/bjoc.12.190

• -Iminoazacycloalkanes are cyclic amidines where the formally sp2 nitrogen is exocyclic. These compounds have been described as selective inhibitors of the inducible form of human nitric oxide synthase (iNOS), which catalyzes the reaction to form nitric oxide via the oxidation of L-arginine to L-citrulline [3][4][5][6

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole- based inhibitors of neuronal nitric oxide synthase

• Graham R. Lawton,
• Haitao Ji,
• Pavel Martásek,
• Linda J. Roman and
• Richard B. Silverman

Beilstein J. Org. Chem. 2009, 5, No. 28, doi:10.3762/bjoc.5.28

• these and other diseases, and to design inhibitors with therapeutic value, nNOS must be inhibited selectively without inhibition of the other isoforms, inducible NOS (iNOS) and endothelial NOS (eNOS); inhibition of eNOS could lead to side effects such as hypertension [5]. Designing therapeutically

• ], and murine iNOS [23] using a hemoglobin capture assay [24], giving Ki values of 10 μM, 1 mM and 50 μM, respectively. This corresponds to a significant loss in potency toward nNOS relative to lead compound 2 [Ki(nNOS) = 0.085 μM, Ki(eNOS) = 85 μM, Ki(iNOS] = 9 μM), suggesting that the aminopyridine