Beilstein J. Org. Chem.2020,16, 2193–2200, doi:10.3762/bjoc.16.184
-fluoroalkylated indenols, together with a very small amount of 3-fluoroalkylated indanones as side products.
Keywords: [2 + 3] cycloaddition; cobalt catalyst; fluorine-containing; indenols; regioselective; Introduction
2,3-Disubstituted indenol derivatives are important compounds possessing high potential due
bring about an increasing effect on the pharmacological activity owing to the unique nature of the fluorine atom(s) [13][14][15][16][17][18]. However, reports on a synthetic protocol for 2- or 3-fluoroalkylated indenols are very limited [19][20][21][22]. Recently, Yamazaki et al. have reported the
best of our knowledge, there are no reports on the practical synthesis of disubstituted 2-fluoroalkylated indenols so far.
Transition-metal-catalyzed carbocyclization reactions of alkynes with benzene derivatives having a leaving group X (X = Br, I, OTs, B(OH)2) have been widely considered as one of