Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

• Jorge de Lima Neto and
• Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

• called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis. Keywords: combretastatin D; corniculatolide; isocorniculatolide

• -methylcorniculatolide A (5, 10 mg), 12-hydroxy-11-O-methylcorniculatolide A (6, 1 mg) and 11-O-methylisocorniculatolide A (8, 2 mg). The authors had some difficulties to isolate isocorniculatolide A (5) using chromatography, however, it was obtained by crystallization from hexane and acetone (4 mg). The same strategy

• was used to isolate the known compound corniculatolide A (4, 10 mg) as colorless crystals [14]. Later the same group reported the isolation of corniculatolide B (9), isocorniculatolide B (10), and corniculatolide C (11) from Xylocarpus granatum, a tree commonly found in Southeast Asia and along the