Short synthesis of the common trisaccharide core of kankanose and kankanoside isolated from Cistanche tubulosa

• Goutam Guchhait and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2013, 9, 705–709, doi:10.3762/bjoc.9.80

• Goutam Guchhait Anup Kumar Misra Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India 10.3762/bjoc.9.80 Abstract A short synthetic approach was developed for the synthesis of a common trisaccharide core found in kankanose, kankanoside F, H1, H2, and I

• isolated from the medicinally active plant Cistanche tubulosa. All glycosylations were carried out under nonmetallic reaction conditions. Yields were very good in all intermediate steps. Keywords: Cistanche tubulosa; glycosylation; kankanoside; synthesis; trisaccharide; Introduction Cistanche tubulosa (C

• . isolated and characterized a significant number of phenylethyl oligosaccharides, which include kankanose, kankanoside F, H1, H2, I, etc. [4][5]. Since C. tubulosa has been used in the folk medicine for several years, it is beneficial to find out the biological activities of the individual compounds present