Beilstein J. Org. Chem.2022,18, 549–554, doi:10.3762/bjoc.18.57
Martin Posta Vaclav Zima Lenka Postova Slavetinska Marika Matousova Petr Beier Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo nám. 2, 16610 Prague 6, Czech Republic 10.3762/bjoc.18.57 Abstract The only known sulfur-containing karrikin, 3-methyl-2H-thiopyrano[3,4
; butenolides; karrikin; sulfur; Introduction
Neurological disorders, especially the Alzheimer’s and the Parkinson’s diseases represent a serious problem for elderly populations worldwide. Studies of these neurodegenerative diseases led to the discovery of a deficit of acetylcholine and dopamine levels in the
concentrations [11][12][13][14]. Structurally, the karrikin backbone consists of a fused pyran and a furanone ring. Each particular molecule differs in the number of methyl groups in positions C3, C5 and C7. Structures of the four most active and abundant karrikins (KAR1–KAR4) are depicted in Figure 1. The
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Graphical Abstract
Figure 1:
Structures of naturally occurring karrikins.