Beilstein J. Org. Chem.2022,18, 1560–1566, doi:10.3762/bjoc.18.166
.18.166 Abstract Longicatenamides A–D are cyclic hexapeptides isolated from the combined culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596. Because these peptides are not detected in the monoculture broth of the actinomycete, they are key tools for understanding chemical
longicatenamide A was confirmed. The developed solid-phase synthesis is expected to facilitate the rapid synthesis of diverse synthetic analogues.
Keywords: antimicrobial; longicatenamides; peptidic natural product; solid-phase synthesis; total synthesis; Introduction
Naturally occurring bioactive compounds can
the combined-culture strategy and new labeling reagents has led to the detection and structural determination of several unprecedented secondary metabolites [5][6][7].
Longicatenamides A–D (1–4, Figure 1) are cyclic hexapeptides isolated from the combined-culture of Streptomyces sp. KUSC_F05 and T
PDF
Graphical Abstract
Figure 1:
Structures of longicatenamides A–D (1–4).