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Search for "main group" in Full Text gives 33 result(s) in Beilstein Journal of Organic Chemistry.
Syntheses and applications of furanyl-functionalised 2,2’:6’,2’’-terpyridines
- Jérôme Husson and
- Michael Knorr
Beilstein J. Org. Chem. 2012, 8, 379–389, doi:10.3762/bjoc.8.41
- as N-donor ligands toward numerous main-group, transition-metal and lanthanide cations [3]. Coordination compounds LnM(tpy)m (n = 0–4; m = 1,2) ligated with terpyridine derivatives form stable assemblies due to the thermodynamic chelate effect. In the case of transition metal complexes, the σ-donor/π
Graphical Abstract
Figure 1: Structure and atomic numbering of 2,2’:6’,2’’-terpyridines.
Scheme 1: Synthesis of furanyl-substituted terpyridines 12–14 by using Kröhnke’s method.
Scheme 2: Synthesis of terpyridines under solvent-free conditions.
Scheme 3: Preparation of 4,4′,4′′-trisubstituted terpyridine containing carboxylate moieties.
Scheme 4: Synthetic pathway for the preparation of a furanyl-functionalised quinquepyridine.
Scheme 5: Utilization of an iminium salt in the preparation of a furanyl-substituted tpy.
Figure 2: Chemical structure of U- and S-shaped isomers.
Scheme 6: Preparation of an asymmetric furanyl-substituted terpyridine.
Scheme 7: Synthesis of tpy by Stille cross-coupling reaction.
Scheme 8: Oxidation of the furan ring of furanyl-substituted terpyridines.
Scheme 9: Direct oxidation of a furan ring attached on Ru(II) tpy complexes.
Figure 3: Example of polyoxometalate frameworks functionalised with tpy ligands and tpy-complex (reprinted wi...
Scheme 10: Synthetic pathway to europium(III) and samarium(III) chelates 56 and 57.
Scheme 11: Synthetic pathway to prepare thiocyanato-functionalised tpys as potential biomolecule-labelling age...
Scheme 12: Synthetic sequence envisioned for biomolecules labelling by click-chemistry.
Figure 4: Structure of pyrrolyl (66), thienyl (67) and bithienyl (68)-substituted complexes analogous to comp...
Synthesis and mesomorphic properties of calamitic malonates and cyanoacetates tethered to 4-cyanobiphenyls
- Katharina C. Kress,
- Martin Kaller,
- Kirill V. Axenov,
- Stefan Tussetschläger and
- Sabine Laschat
Beilstein J. Org. Chem. 2012, 8, 371–378, doi:10.3762/bjoc.8.40
- malonates and cyanoacetates are well known as suitable ligands for strong coordination of main-group and transition metals [25]. Benzylidene derivatives of malonic esters, so called swallow-tailed liquid crystals, were described as forming smectic phases [26]. However, most work on liquid-crystalline
Graphical Abstract
Scheme 1: Diketonato metallomesogens and diketones with mesomorphic properties.
Scheme 2: Malonates and cyanoacetates tethered to calamitic 4-cyanobiphenyl units.
Scheme 3: Synthesis of malonate and cyanoacetates tethered to 4-cyano-biphenyl moieties.
Figure 1: DSC traces of 13a (heating/cooling rate 5 K/min).
Figure 2: DSC traces of 11a (heating/cooling rate 10 K/min).
Figure 3: Schlieren textures of 11a and 11b under crossed polarizers, upon cooling (cooling rate 5 K/min) fro...
Figure 4: Schlieren textures of 13a and 13b under crossed polarizers upon cooling (cooling rate 5 K/min) from...
Figure 5: 2D X-ray scattering patterns of 11a: (A) crystalline phase at 50 °C, (B) isotropic phase at 25 °C, ...
Synthesis and oxidation of some azole-containing thioethers
- Andrei S. Potapov,
- Nina P. Chernova,
- Vladimir D. Ogorodnikov,
- Tatiana V. Petrenko and
- Andrei I. Khlebnikov
Beilstein J. Org. Chem. 2011, 7, 1526–1532, doi:10.3762/bjoc.7.179
- ligands, forming complexes with most transition metals and some main-group elements [1]. The coordinating ability of these ligands can be diversified by the introduction of additional donor atoms into the spacer between the heterocycles. Ligands with spacers bearing nitrogen, oxygen, and sulfur atoms have
Graphical Abstract
Scheme 1: Synthesis of azole-containing thioethers.
Scheme 2: Synthesis of dithioether.
Scheme 3: Oxidation of thioethers to sulfoxides and sulfones.
Scheme 4: Preparation of functional derivatives.
Figure 1: Energies and isosurfaces of the highest occupied molecular orbitals (HOMO) of azole-containing thio...
Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents
- Paul Knochel,
- Matthias A. Schade,
- Sebastian Bernhardt,
- Georg Manolikakes,
- Albrecht Metzger,
- Fabian M. Piller,
- Christoph J. Rohbogner and
- Marc Mosrin
Beilstein J. Org. Chem. 2011, 7, 1261–1277, doi:10.3762/bjoc.7.147
- transition metal salts and in a very limited scope. Recently, we showed that the cheap and non-toxic main group Lewis acid MgCl2 allows smooth addition reactions of different aromatic, heteroaromatic, alkyl and benzylic zinc reagents to various carbonyl derivatives and carbon dioxide without the use of polar
Graphical Abstract
Scheme 1: Preparation of polyfunctional heteroarylzinc reagents.
Scheme 2: LiCl-mediated insertion of zinc dust to aryl and heteroaryl iodides.
Scheme 3: Selective insertions of Zn in the presence of LiCl.
Scheme 4: Chemoselective insertion of zinc in the presence of LiCl.
Scheme 5: Preparation and reactions of benzylic zinc reagents.
Scheme 6: Ni-catalyzed cross-coupling of benzylic zinc reagent 34 with ethyl 2-chloronicotinate.
Scheme 7: In situ generation of arylzinc reagents using Mg in the presence of LiCl and ZnCl2.
Scheme 8: Zincation of heterocycles with TMP2Zn (42).
Scheme 9: Preparation of highly functionalized zincated heterocycles using TMP2Zn·2MgCl2·2LiCl (42).
Scheme 10: Microwave-accelerated zincation of heterocycles using TMP2Zn·2MgCl2·2LiCl (42).
Scheme 11: The I/Mg-exchange as a metal-metathesis reaction.
Scheme 12: Regioselective Br/Mg-exchange of dibromoquinolines 65 and 68.
Scheme 13: Improved reagents for the regioselective Br/Mg-exchange on bromoquinolines.
Scheme 14: Synthesis of ellipticine (83) using an I/Mg-exchange reaction.
Scheme 15: An oxidative amination leading to the biologically active adenine, purvalanol A (84).
Scheme 16: Preparation of polyfunctional arylmagnesium reagents using Mg in the presence of LiCl.
Scheme 17: Preparation of polyfunctional magnesium reagents starting from organic chlorides.
Scheme 18: Selective multiple magnesiation of the pyrimidine ring.
Scheme 19: Synthesis of a p38 kinase inhibitor 119 and of a sPLA2 inhibitor 123.
Scheme 20: Synthesis of highly substituted indoles of type 128.
Scheme 21: Efficient magnesiations of polyfunctional aromatics and heterocycles using TMP2Mg·2LiCl (129).
Scheme 22: Negishi cross-coupling in the presence of substrates bearing an NH- or an OH-group.
Scheme 23: Negishi cross-coupling in the presence of a serine moiety.
Scheme 24: Radical catalysis for the performance of very fast Kumada reactions.
Scheme 25: MgCl2-mediated addition of functionalized aromatic, heteroaromatic, alkyl and benzylic organozincs ...
Stereogenic boron in 2-amino-1,1-diphenylethanol-based boronate–imine and amine complexes
- Sebastian Schlecht,
- Walter Frank and
- Manfred Braun
Beilstein J. Org. Chem. 2011, 7, 615–621, doi:10.3762/bjoc.7.72
- complex 10 was established by separation of the enantiomers. Racemization barriers were found to be in the same range for both amine and imine complexes (100–110 kJ/mol). Keywords: boron; chirality; coordination chemistry; crystal structure; stereochemistry; Introduction Enantiomerism of main group
Graphical Abstract
Scheme 1: Stereogenic boron in resolved acyclic and cyclic complexes 1–4.
Scheme 2: Synthesis of the racemic boronate–imine complex 8 and boronate–amine complex 10. Reagents and condi...
Figure 1: Solid-state structure of boronate–imine complex 8 (a) and the chosen asymmetric unit of the crystal...
Figure 2: Superposition of the skeletons of boronate complexes 8 (red) and 10 (green).
Molecular recognition of organic ammonium ions in solution using synthetic receptors
- Andreas Späth and
- Burkhard König
Beilstein J. Org. Chem. 2010, 6, No. 32, doi:10.3762/bjoc.6.32
- sulfur, or phosphorus or arsenic atoms. Crown ether oxygen atoms as the donor site prefer harder cations of main group elements as guests, while crown ethers with sulphur atoms at the donor site are particularly suitable for the complexation of softer transition metals, e.g. Ag+, Cu2+, Hg2+ [109
Graphical Abstract
Figure 1: Biologically important amines and quaternary ammonium salts: histamine (1), dopamine (2) and acetyl...
Figure 2: Crown ether 18-crown-6.
Figure 3: Conformations of 18-crown-6 (4) in solvents of different polarity.
Figure 4: Binding topologies of the ammonium ion depending on the crown ring size.
Figure 5: A “pseudorotaxane” structure consisting of 24-crown-8 and a secondary ammonium ion (5); R = Ph.
Figure 6: Typical examples of azacrown ethers, cryptands and related aza macrocycles.
Figure 7: Binding of ammonium to azacrown ethers and cryptands [111-113].
Figure 8: A 19-crown-6-ether with decalino blocking groups (11) and a thiazole-dibenzo-18-crown-6-ether (12).
Figure 9: 1,3-Bis(6-oxopyridazin-1-yl)propane derivatives 13 and 14 by Campayo et al.
Figure 10: Fluorescent azacrown-PET-sensors based on coumarin.
Figure 11: Two different pyridino-cryptands (17 and 18) compared to a pyridino-crown (19); chiral ammonium ion...
Figure 12: Pyridino-18-crown-6 ligand (21), a similar acridino-18-crown-6 ligand (22) and a structurally relat...
Figure 13: Ciral pyridine-azacrown ether receptors 24.
Figure 14: Chiral 15-crown-5 receptors 26 and an analogue 18-crown-6 ligand 27 derived from amino alcohols.
Figure 15: C2-symmetric chiral 18-crown-6 amino alcohol derivatives 28 and related macrocycles.
Figure 16: Macrocycles with diamide-diester groups (30).
Figure 17: C2-symmetric chiral aza-18-crown-6 ethers (31) with phenethylamine residues.
Figure 18: Chiral C-pivot p-methoxy-phenoxy-lariat ethers.
Figure 19: Chiral lariat crown ether 34.
Figure 20: Sucrose-based chiral crown ether receptors 36.
Figure 21: Permethylated fructooligosaccharide 37 showing induced-fit chiral recognition.
Figure 22: Biphenanthryl-18-crown-6 derivative 38.
Figure 23: Chiral lariat crown ethers derived from binol by Fuji et al.
Figure 24: Chiral phenolic crown ether 41 with “aryl chiral barriers” and guest amines.
Figure 25: Chiral bis-crown receptor 43 with a meso-ternaphthalene backbone.
Figure 26: Chromogenic pH-dependent bis-crown chemosensor 44 for diamines.
Figure 27: Triamine guests for binding to receptor 44.
Figure 28: Chiral bis-crown phenolphthalein chemosensors 46.
Figure 29: Crown ether amino acid 47.
Figure 30: Luminescent receptor 48 for bis-alkylammonium guests.
Figure 31: Luminescent CEAA (49a), a bis-CEAA receptor for amino acids (49b) and the structure of lysine bindi...
Figure 32: Luminescent CEAA tripeptide for binding small peptides.
Figure 33: Bis crown ether 51a self assembles co-operatively with C60-ammonium ion 51b.
Figure 34: Triptycene-based macrotricyclic dibenzo-[24]-crown-8 ether host 52 and guests.
Figure 35: Copper imido diacetic acid azacrown receptor 53a and the suggested His-Lys binding motif; a copper ...
Figure 36: Urea (54) and thiourea (55) benzo crown receptor for transport and extraction of amino acids.
Figure 37: Crown pyryliums ion receptors 56 for amino acids.
Figure 38: Ditopic sulfonamide bridged crown ether receptor 57.
Figure 39: Luminescent peptide receptor 58.
Figure 40: Luminescent receptor 59 for the detection of D-glucosamine hydrochloride in water/ethanol and lumin...
Figure 41: Guanidinium azacrown receptor 61 for simple amino acids and ditopic receptor 62 with crown ether an...
Figure 42: Chiral bicyclic guanidinium azacrown receptor 63 and similar receptor 64 for the enantioselective t...
Figure 43: Receptors for zwitterionic species based on luminescent CEAAs.
Figure 44: 1,10-Azacrown ethers with sugar podand arms and the anticancer agent busulfan.
Figure 45: Benzo-18-crown-6 modified β-cyclodextrin 69 and β-cyclodextrin functionalized with diaza-18-crown-6...
Figure 46: Receptors for colorimetric detection of primary and secondary ammonium ions.
Figure 47: Porphyrine-crown-receptors 72.
Figure 48: Porphyrin-crown ether conjugate 73 and fullerene-ammonium ion guest 74.
Figure 49: Calix[4]arene (75a), homooxocalix[4]arene (75b) and resorcin[4]arene (75c) compared (R = H, alkyl c...
Figure 50: Calix[4]arene and ammonium ion guest (R = H, alkyl, OAcyl etc.), possible binding sites; A: co-ordi...
Figure 51: Typical guests for studies with calixarenes and related molecules.
Figure 52: Lower rim modified p-tert-butylcalix[5]arenes 82.
Figure 53: The first example of a water soluble calixarene.
Figure 54: Sulfonated water soluble calix[n]arenes that bind ammonium ions.
Figure 55: Displacement assay for acetylcholine (3) with a sulfonato-calix[6]arene (84b).
Figure 56: Amino acid inclusion in p-sulfonatocalix[4]arene (84a).
Figure 57: Calixarene receptor family 86 with upper and lower rim functionalization.
Figure 58: Calix[6]arenes 87 with one carboxylic acid functionality.
Figure 59: Sulfonated calix[n]arenes with mono-substitution at the lower rim systematically studied on their r...
Figure 60: Cyclotetrachromotropylene host (91) and its binding to lysine (81c).
Figure 61: Calixarenes 92 and 93 with phosphonic acids groups.
Figure 62: Calix[4]arene tetraphosphonic acid (94a) and a double bridged analogue (94b).
Figure 63: Calix[4]arene tetraphosphonic acid ester (92c) for surface recognition experiments.
Figure 64: Calixarene receptors 95 with α-aminophosphonate groups.
Figure 65: A bridged homocalix[3]arene 95 and a distally bridged homocalix[4]crown 96.
Figure 66: Homocalix[3]arene ammonium ion receptor 97a and the Reichardt’s dye (97b) for colorimetric assays.
Figure 67: Chromogenic diazo-bridged calix[4]arene 98.
Figure 68: Calixarene receptor 99 by Huang et al.
Figure 69: Calixarenes 100 reported by Parisi et al.
Figure 70: Guest molecules for inclusion in calixarenes 100: DAP × 2 HCl (101a), APA (101b) and Lys-OMe × 2 HC...
Figure 71: Different N-linked peptido-calixarenes open and with glycol chain bridges.
Figure 72: (S)-1,1′-Bi-2-naphthol calixarene derivative 104 published by Kubo et al.
Figure 73: A chiral ammonium-ion receptor 105 based on the calix[4]arene skeleton.
Figure 74: R-/S-phenylalaninol functionalized calix[6]arenes 106a and 106b.
Figure 75: Capped homocalix[3]arene ammonium ion receptor 107.
Figure 76: Two C3 symmetric capped calix[6]arenes 108 and 109.
Figure 77: Phosphorous-containing rigidified calix[6]arene 110.
Figure 78: Calix[6]azacryptand 111.
Figure 79: Further substituted calix[6]azacryptands 112.
Figure 80: Resorcin[4]arene (75c) and the cavitands (113).
Figure 81: Tetrasulfonatomethylcalix[4]resorcinarene (114).
Figure 82: Resorcin[4]arenes (115a/b) and pyrogallo[4]arenes (115c, 116).
Figure 83: Displacement assay for acetylcholine (3) with tetracyanoresorcin[4]arene (117).
Figure 84: Tetramethoxy resorcinarene mono-crown-5 (118).
Figure 85: Components of a resorcinarene based displacement assay for ammonium ions.
Figure 86: Chiral basket resorcin[4]arenas 121.
Figure 87: Resorcinarenes with deeper cavitand structure (122).
Figure 88: Resorcinarene with partially open deeper cavitand structure (123).
Figure 89: Water-stabilized deep cavitands with partially structure (124, 125).
Figure 90: Charged cavitands 126 for tetralkylammonium ions.
Figure 91: Ditopic calix[4]arene receptor 127 capped with glycol chains.
Figure 92: A calix[5]arene dimer for diammonium salt recognition.
Figure 93: Calixarene parts 92c and 129 for the formation molecular capsules.
Figure 94: Encapsulation of a quaternary ammonium cation by two resorcin[4]arene molecules (NMe4+@[75c]2 × Cl−...
Figure 95: Encapsulation of a quaternary ammonium cation by six resorcin[4]arene molecules (NMe3D+@[130]6 × Cl−...
Figure 96: Structure and schematic of cucurbit[6]uril (CB[6], 131a).
Figure 97: Cyclohexanocucurbit[6]uril (CB′[6], 132) and the guest molecule spermine (133).
Figure 98: α,α,δ,δ-Tetramethylcucurbit[6]uril (134).
Figure 99: Structure of the cucurbituril-phthalhydrazide analogue 135.
Figure 100: Organic cavities for the displacement assay for amine differentiation.
Figure 101: Displacement assay methodology for diammonium- and related guests involving cucurbiturils and some ...
Figure 102: Nor-seco-Cucurbituril (±)-bis-ns-CB[6] (140) and guest molecules.
Figure 103: The cucurbit[6]uril based complexes 141 for chiral discrimination.
Figure 104: Cucurbit[7]uril (131c) and its ferrocene guests (142) opposed.
Figure 105: Cucurbit[7]uril (131c) guest inclusion and representative guests.
Figure 106: Cucurbit[7]uril (131c) binding to succinylcholine (145) and different bis-ammonium and bis-phosphon...
Figure 107: Paraquat-cucurbit[8]uril complex 149.
Figure 108: Gluconuril-based ammonium receptors 150.
Figure 109: Examples of clefts (151a), tweezers (151b, 151c, 151d) and clips (151e).
Figure 110: Kemp’s triacid (152a), on example of Rebek’s receptors (152b) and guests.
Figure 111: Amino acid receptor (154) by Rebek et al.
Figure 112: Hexagonal lattice designed hosts by Bell et al.
Figure 113: Bell’s amidinium receptor (156) and the amidinium ion (157).
Figure 114: Aromatic phosphonic acids.
Figure 115: Xylene phosphonates 159 and 160a/b for recognition of amines and amino alcohols.
Figure 116: Bisphosphonate recognition motif 161 for a colorimetric assay with alizarin complexone (163) for ca...
Figure 117: Bisphosphonate/phosphate clip 164 and bisphosphonate cleft 165.
Figure 118: N-Methylpyrazine 166a, N-methylnicotinamide iodide (166b) and NAD+ (166c).
Figure 119: Bisphosphate cavitands.
Figure 120: Bisphosphonate 167 of Schrader and Finocchiaro.
Figure 121: Tweezer 168 for noradrenaline (80b).
Figure 122: Different tripods and heparin (170).
Figure 123: Squaramide based receptors 172.
Figure 124: Cage like NH4+ receptor 173 of Kim et al.
Figure 125: Ammonium receptors 174 of Chin et al.
Figure 126: 2-Oxazolin-based ammonium receptors 175a–d and 176 by Ahn et al.
Figure 127: Racemic guest molecules 177.
Figure 128: Tripods based on a imidazole containing macrocycle (178) and the guest molecules employed in the st...
Figure 129: Ammonium ion receptor 180.
Figure 130: Tetraoxa[3.3.3.3]paracyclophanes 181 and a cyclophanic tetraester (182).
Figure 131: Peptidic bridged paraquat-cyclophane.
Figure 132: Shape-selective noradrenaline host.
Figure 133: Receptor 185 for binding of noradrenaline on surface layers from Schrader et al.
Figure 134: Tetraphosphonate receptor for binding of noradrenaline.
Figure 135: Tetraphosphonate 187 of Schrader and Finocchiaro.
Figure 136: Zinc-Porphyrin ammonium-ion receptors 188 and 189 of Mizutani et al.
Figure 137: Zinc porphyrin receptor 190.
Figure 138: Zinc porphyrin receptors 191 capable of amino acid binding.
Figure 139: Zinc-porphyrins with amino acid side chains for stereoinduction.
Figure 140: Bis-zinc-bis-porphyrin based on Tröger’s base 193.
Figure 141: BINAP-zinc-prophyrin derivative 194 and it’s guests.
Figure 142: Bisaryl-linked-zinc-porphyrin receptors.
Figure 143: Bis-zinc-porphyrin 199 for diamine recognition and guests.
Figure 144: Bis-zinc-porphyrin crown ether 201.
Figure 145: Bis-zinc-porphyrin 202 for stereodiscrimination (L = large substituent; S = small substituent).
Figure 146: Bis-zinc-porphyrin[3]rotaxane and its copper complex and guests.
Figure 147: Dien-bipyridyl ligand 206 for co-ordination of two metal atoms.
Figure 148: The ligand and corresponding tetradentate co-complex 207 serving as enantioselective receptor for a...
Figure 149: Bis(oxazoline)–copper(II) complex 208 for the recognition of amino acids in aqueous solution.
Figure 150: Zinc-salen-complexes 209 for the recognition tertiary amines.
Figure 151: Bis(oxazoline)–copper(II) 211 for the recognition of amino acids in aqueous solution.
Figure 152: Zn(II)-complex of a C2 terpyridine crown ether.
Figure 153: Displacement assay and receptor for aspartate over glutamate.
Figure 154: Chiral complex 214 for a colorimetric displacement assay for amino acids.
Figure 155: Metal complex receptor 215 with tripeptide side arms.
Figure 156: A sandwich complex 216 and its displaceable dye 217.
Figure 157: Lanthanide complexes 218–220 for amino acid recognition.
Figure 158: Nonactin (221), valinomycin (222) and vancomycin (223).
Figure 159: Monesin (224a) and a chiral analogue for enantiodiscrimination of ammonium guests (224b).
Figure 160: Chiral podands (226) compared to pentaglyme-dimethylether (225) and 18-crown-6 (4).
Figure 161: Lasalocid A (228).
Figure 162: Lasalocid derivatives (230) of Sessler et al.
Figure 163: The Coporphyrin I tetraanion (231).
Figure 164: Linear and cyclic peptides for ammonium ion recognition.
Figure 165: Cyclic and bicyclic depsipeptides for ammonium ion recognition.
Figure 166: α-Cyclodextrin (136a) and novocaine (236).
Figure 167: Helical diol receptor 237 by Reetz and Sostmann.
Figure 168: Ammonium binding spherand by Cram et al. (238a) and the cyclic[6]metaphenylacetylene 238b in compar...
Figure 169: Receptor for peptide backbone and ammonium binding (239).
Figure 170: Anion sensor principle with 3-hydroxy-2-naphthanilide of Jiang et al.
Figure 171: 7-bromo-3-hydroxy-N-(2-hydroxyphenyl)naphthalene 2-carboxamide (241) and its amine binding.
Figure 172: Naturally occurring catechins with affinity to quaternary ammonium ions.
Figure 173: Spiropyran (244) and merocyanine form (244a) of the amino acid receptors of Fuji et al.
Figure 174: Coumarin aldehyde (245) and its iminium species with amino acid bound (245a) by Glass et al.
Figure 175: Coumarin aldehyde appended with boronic acid.
Figure 176: Quinolone aldehyde dimers by Glass et al.
Figure 177: Chromogenic ammonium ion receptors with trifluoroacetophenone recognition motifs.
Figure 178: Chromogenic ammonium ion receptor with trifluoroacetophenone recognition motif bound on different m...
Synthesis and properties of calix[4]arene telluropodant ethers as Ag+ selective sensors and Ag+, Hg2+ extractants
- Yang Lu,
- Yuanyuan Li,
- Song He,
- Yan Lu,
- Changying Liu,
- Xianshun Zeng and
- Langxing Chen
Beilstein J. Org. Chem. 2009, 5, No. 59, doi:10.3762/bjoc.5.59
- the receptors showed very weak extraction ability towards Li+, Na+, K+, Ca2+, which meant that these ionophores had weak affinity for these main Group cations. It was noteworthy that the soft Ag+ and Hg2+ ions were almost quantitatively extracted by calix[4]arenes 6–8. The cone conformer 10 exhibited
Graphical Abstract
Scheme 1: Synthesis and structures of calix[4]arenes 6–8; 3, 6: n = 2; 4, 7: n = 3; 5, 8: n = 5.
Scheme 2: Synthesis of calix[4]arene 10 and 12.
Preparation and Diels–Alder/cross coupling reactions of a 2-diethanolaminoboron- substituted 1,3-diene
- Liqiong Wang,
- Cynthia S. Day,
- Marcus W. Wright and
- Mark E. Welker
Beilstein J. Org. Chem. 2009, 5, No. 45, doi:10.3762/bjoc.5.45
- 2 is by far the most reactive main group element substituted diene we have made in the boron or silicon substituted series to date. What is perhaps even more surprising to us is that this diene 2 is even more reactive than the most reactive cobaloxime substituted diene we ever prepared in our
- regioselectivities observed in the original Diels–Alder reactions were maintained after cross coupling. Conclusion In conclusion, we report a simple preparation of a 2-boronyl substituted 1,3 diene which has proved to be the most reactive 2-main group element or 2-transition metal element substituted diene for Diels
Graphical Abstract
Scheme 1: Synthesis of 2-diethanolaminoborate-1,3-butadiene.
Figure 1: Molecular structure of boron substituted diene 2.
Scheme 2: Diels–Alder reactions.
Scheme 3: Cross coupling reactions.
