First synthesis of 2-(benzofuran-2-yl)-6,7-methylene dioxyquinoline-3-carboxylic acid derivatives

• Wentao Gao,
• Jia Liu,
• Yun Jiang and
• Yang Li

Beilstein J. Org. Chem. 2011, 7, 210–217, doi:10.3762/bjoc.7.28

• Wentao Gao Jia Liu Yun Jiang Yang Li Institute of Superfine Chemicals, Bohai University, Jinzhou 121000, China 10.3762/bjoc.7.28 Abstract A facile and inexpensive synthesis of a series of novel methylenedioxy-bearing 2-(benzofuran-2-yl)-quinoline-3-carboxylic acid derivatives 3a–h via the one-pot

• ; methylenedioxy-bearing; one-pot; quinoline-3-carboxylic acid; salicylaldehyde; Introduction Heterocyclic systems containing a quinoline nucleus are an important group of compounds in medicinal chemistry, and are ubiquitous sub-structures associated with biologically active natural products [1][2][3][4]. Some

• against human cancer cell lines, the methylenedioxy-bearing 2-PQ was identified as the most active compound in vivo [25]. In light of these findings and in view of structural diversity which plays a prominent role in medicinal and combinatorial chemistry and which leads to a faster and more efficient lead