Beilstein J. Org. Chem.2022,18, 1032–1039, doi:10.3762/bjoc.18.104
monomethylamines by reduction of N-substituted carbonylimidazoles with NaBH4/I2 in THF at reflux temperature is described. This method used no special catalyst and various monomethylamines can be easily obtained in moderate to good yields from a wide range of raw materials including amines (primary amines and
-determining step. This work can contribute significantly expanding the applications of N-substituted carbonylimidazoles.
Keywords: amines; carboxylic acids; isocyanates; monomethylamines; N-substituted carbonylimidazoles; reduction; Introduction
N-Methylamines are widely found in natural products, fine
method is to introduce alkyl formate, formacyl, methylene or their equivalents to amines, followed by reduction to give monomethylamines [44][45][46][47][48][49][50][51]. Protection/methylation/deprotection strategies have also been developed for the preparation of monomethylation objects, which are
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Graphical Abstract
Scheme 1:
The synthesis of formamides and monomethylamines.