Inductive heating and flow chemistry – a perfect synergy of emerging enabling technologies

• Conrad Kuhwald,
• Sibel Türkhan and
• Andreas Kirschning

Beilstein J. Org. Chem. 2022, 18, 688–706, doi:10.3762/bjoc.18.70

• , they are less common due to their inherent toxicity and ease of oxidation. Another branch of research involving SPIONs focuses on developments in nanoscience, nanomedicine, and nanoparticle-assisted imaging, diagnosis, and drug delivery [4][5][6][7], an area that is not covered in this report. Review 1

Stepwise PEG synthesis featuring deprotection and coupling in one pot

• Logan Mikesell,
• Dhananjani N. A. M. Eriyagama,
• Yipeng Yin,
• Bao-Yuan Lu and
• Shiyue Fang

Beilstein J. Org. Chem. 2021, 17, 2976–2982, doi:10.3762/bjoc.17.207

• obtained. We expect that the one-pot PEG elongation approach will be helpful to make monodisperse PEGs more affordable and has a positive impact in areas such as bioconjugation and nanomedicine where monodisperse PEGs are needed. A comparison of the new PEG synthesis method with a typical known PEG

Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches

• Tobias Klein,
• Franka V. Gruschwitz,
• Maren T. Kuchenbrod,
• Ivo Nischang,
• Stephanie Hoeppener and
• Johannes C. Brendel

Beilstein J. Org. Chem. 2021, 17, 2621–2628, doi:10.3762/bjoc.17.175

• desired applications in nanomedicine [4][5]. A key factor in this regard are formulation strategies, which allow a straightforward implementation into established processes that are, e.g., in accordance with good manufacturing practice (GMP) [6]. Approaches such as the crystallization-driven self-assembly

• control of the assembly pathway and requires the use of organic solvents, such as THF and DMF, which limits the applicability in pharmaceutical formulations [21]. For an application in nanomedicine, a length in the range of 100–200 nm is particularly attractive to ensure cellular uptake and to access the

Antiviral therapy in shrimp through plant virus VLP containing VP28 dsRNA against WSSV

• Santiago Ramos-Carreño,
• Ivone Giffard-Mena,
• Jose N. Zamudio-Ocadiz,
• Alfredo Nuñez-Rivera,
• Ricardo Valencia-Yañez,
• Jaime Ruiz-Garcia,
• Maria Teresa Viana and
• Ruben D. Cadena-Nava

Beilstein J. Org. Chem. 2021, 17, 1360–1373, doi:10.3762/bjoc.17.95

• applied to pathogen control in shrimp and also other organisms, widening the application window in nanomedicine. Keywords: antiviral therapy; CCMV; oral administration; P. vannamei; plant VLPs; RNAi; VP28; white spot syndrome virus; Introduction The white spot syndrome virus (WSSV) is recognized as one

• ) has been extensively studied and characterized, due to its potential applications in nanomedicine [33][36][39][40][41]. Native CCMV has a positive single-stranded RNA. It is a Bromoviridae family member that infects cowpea (Vigna unguiculata) plants. The CCMV VLPs with heterologous RNA has already

• molecules. The antiviral therapy here presented could be applied, with further research, to other aquatic species or even terrestrial organisms, or within nanomedicine applications. Analysis of the VLP-dsRNAvp28 assembly by electrophoresis mobility shift assay (EMSA) in a 1% native agarose gel. Lane 1 is

Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers

• Alberto Rubin Pedrazzo,
• Fabrizio Caldera,
• Marco Zanetti,
• Silvia Lucia Appleton,
• Nilesh Kumar Dhakar and
• Francesco Trotta

Beilstein J. Org. Chem. 2020, 16, 1554–1563, doi:10.3762/bjoc.16.127

• , and rhodamine B) and the still reactive imidazoyl carbonyl group of the NS. Keywords: β-cyclodextrin; ball-milling; crosslinking; green chemistry; mechanochemistry; nanosponges; Introduction The research in the fields of nanomedicine and nanotechnology has nowadays become predominant

Glyco-gold nanoparticles: synthesis and applications

• Federica Compostella,
• Olimpia Pitirollo,
• Alessandro Silvestri and
• Laura Polito

Beilstein J. Org. Chem. 2017, 13, 1008–1021, doi:10.3762/bjoc.13.100

• , gold can be easily and covalently decorated on its surface by exploiting the strong soft–soft interaction between a Au atom and sulfur [8]. Therefore, glyco-gold nanoparticles (GAuNPs) represent a smart, multimodal and versatile nanoplatform to develop carbohydrate-based nanotechnology and nanomedicine

• by carbohydrates, GAuNPs hold great potentiality in bio-nanomedicine. In this review, we have attempted to summarize the last results obtained in this field, anticipating the numerous applications with a detailed description and implication of each part of the hybrid system. A careful GAuNP design

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

• Stephen Hill and
• M. Carmen Galan

Beilstein J. Org. Chem. 2017, 13, 675–693, doi:10.3762/bjoc.13.67

• , chemical sensing, biosensing, bioimaging and nanomedicine, due to their unique tuneable photoluminescence (PL) properties, chemical inertness, high water solubility, ease and low cost fabrication and more importantly, low toxicity profiles. The latter makes these fluorescent nanomaterials attractive for a

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

• Eric Buchy,
• Branko Vukosavljevic,
• Maike Windbergs,
• Dunja Sobot,
• Camille Dejean,
• Simona Mura,
• Patrick Couvreur and
• Didier Desmaële

Beilstein J. Org. Chem. 2016, 12, 1127–1135, doi:10.3762/bjoc.12.109

• : deuterium labelling; nanomedicine; Raman spectroscopy; Shapiro reaction; squalene; Introduction Application of nanotechnology to medicine holds promises to profoundly impact healthcare especially to treat severe diseases such as cancer, intracellular infections, neurodegenerative diseases, etc. Indeed, the

• , its coupling with gemcitabine and the Raman spectra of the deuterated GemSQ nanoassemblies, opening the way to perform intracellular imaging of squalenoyl nanomedicine (Figure 1). Results and Discussion Chemical synthesis of squalenic acid-d6 and GemSQ-d6 conjugate In a first approach we decided to

Aggregation behavior of amphiphilic cyclodextrins in a nonpolar solvent: evidence of large-scale structures by atomistic molecular dynamics simulations and solution studies

• Giuseppina Raffaini,
• Fabio Ganazzoli and
• Antonino Mazzaglia

Beilstein J. Org. Chem. 2016, 12, 73–80, doi:10.3762/bjoc.12.8

• potential use in nanomedicine, as pointed out in the Introduction, even though the use of nonpolar solvents could also be relevant for preparative or characterization purposes. In the present work, we report an investigation by means of dynamic light scattering on the aggregation properties of the compound

Synthesis of D-fructose-derived spirocyclic 2-substituted-2-oxazoline ribosides

• Madhuri Vangala and
• Ganesh P. Shinde

Beilstein J. Org. Chem. 2015, 11, 2289–2296, doi:10.3762/bjoc.11.249

• stable, conformationally constrained riboside spirooxazolines open up the possible application in the development of new drug molecules. In addition, these highly functionalized glycooxazolines can be used to make covalently cross-linked polymers for application in nanomedicine and material science. Some

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

• Hale Ünal,
• Naile Öztürk and
• Erem Bilensoy

Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22

• Hale Unal Naile Ozturk Erem Bilensoy Division of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Beytepe, Ankara, 06800, Turkey Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sıhhıye, Ankara, 06100, Turkey

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• Fabrizio Chiodo,
• Marco Marradi,
• Javier Calvo,
• Eloisa Yuste and
• Soledad Penadés

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

• Fabrizio Chiodo Marco Marradi Javier Calvo Eloisa Yuste Soledad Penades Laboratory of GlycoNanotechnology, Biofunctional Nanomaterials Unit, CIC biomaGUNE, Paseo Miramón 182, 20009, San Sebastián, Spain Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Paseo

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine. Keywords: controlled release

• nanoscale structural characteristics can be expected to provide many potential applications in the field of nanomedicine. Cyclodextrins [1][2][3] are nanometric biomaterials with a close relationship between molecular status and supramolecular properties. They are a class of cyclic glucopyranose oligomers

• molecules in nanomedicine. Molecular structure of cyclodextrin carbonate nanosponges. TEM microphotograph of cyclodextrin carbonate nanosponge (magnification 46,000×). Synthetic routes to cyclodextrin nanosponges. (a) Cyclodextrin carbonate nanosponges. (b) Cyclodextrin carboxylate nanosponges. Molecules

Low-generation dendrimers with a calixarene core and based on a chiral C₂-symmetric pyrrolidine as iminosugar mimics

• Marco Marradi,
• Stefano Cicchi,
• Francesco Sansone,
• Alessandro Casnati and
• Andrea Goti

Beilstein J. Org. Chem. 2012, 8, 951–957, doi:10.3762/bjoc.8.107

• thanks the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). AC and MM acknowledge COST action CM1102. AC and FS also acknowledge PRIN200858SA98 for partial support.

Liquid-crystalline nanoparticles: Hybrid design and mesophase structures

• Gareth L. Nealon,
• Romain Greget,
• Cristina Dominguez,
• Zsuzsanna T. Nagy,
• Daniel Guillon,
• Jean-Louis Gallani and
• Bertrand Donnio

Beilstein J. Org. Chem. 2012, 8, 349–370, doi:10.3762/bjoc.8.39

• growth. These properties have led to their exploitation in a number of applications, from catalysis and molecular electronics to nanomedicine [77], and their use in liquid crystal applications is relatively well established [31][78]. Recognising this potential, a study was reported [79] in which a series