Mixtures of monodentate P-ligands as a means to control the diastereoselectivity in Rh-catalyzed hydrogenation of chiral alkenes

• Manfred T. Reetz and
• Hongchao Guo

Beilstein J. Org. Chem. 2005, 1, No. 3, doi:10.1186/1860-5397-1-3

• precursor Rh(nbd)2BF4 (nbd = norbornadiene) was treated with the ligands to form pre-catalysts of the type RhL2(nbd)BF4 and free nbd. Dichloromethane served as the solvent. In the case of the hydrogenation of the allylic alcohol 1, 21 of the 23 ligands were employed, which means a total of 210 different