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Search for "organelle" in Full Text gives 11 result(s) in Beilstein Journal of Organic Chemistry.
Substrate specificity of a ketosynthase domain involved in bacillaene biosynthesis
Beilstein J. Org. Chem. 2024, 20, 734–740, doi:10.3762/bjoc.20.67
- cooperate with the PKS “in trans” [11][12]. Notably, in B. subtilis the giant bacillaene biosynthesis machinery forms an organelle-like complex that can be observed through cryoelectron microscopy [13]. The structure elucidation of “bacillaene” through extensive NMR spectroscopic methods revealed the
Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides
Beilstein J. Org. Chem. 2020, 16, 2007–2016, doi:10.3762/bjoc.16.167
- underexpression of the fusion protein, and undesired localization out of the selected organelle. To explore how automated HC imaging can handle these problems, a whole-cell body mask was applied first (Figure 10a, cyan, including yellow). With this mask, the fluorescence of GFP and 26 correlated with r2 = 0.626
Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos
Beilstein J. Org. Chem. 2020, 16, 39–49, doi:10.3762/bjoc.16.6
- differences of erythrocytes compared to other somatic cells. Although easily measured, hemolytic activity gives only a rough estimate of toxicity for peptide therapeutics. Erythrocytes are terminally differentiated non-adherent organelle-free cells, densely packed with oxygen-carrying proteins; their
Synthesis of a dihalogenated pyridinyl silicon rhodamine for mitochondrial imaging by a halogen dance rearrangement
Beilstein J. Org. Chem. 2019, 15, 2333–2343, doi:10.3762/bjoc.15.226
- of 0.34, comparable to other organelle targeting SiR derivatives and absorbs at 665 nm (εmax = 34 000 M−1cm−1) and emits at 681 nm (τ = 1.9 ns). Using colocalization experiments with MitoTracker® Green FM, we could prove the intrinsic targeting ability to mitochondria in two human cell lines (Pearson
Archangelolide: A sesquiterpene lactone with immunobiological potential from Laserpitium archangelica
Beilstein J. Org. Chem. 2019, 15, 1933–1944, doi:10.3762/bjoc.15.189
- partial co-localization also in mitochondria, in which SERCA is not present. Localization of a control (dansyl fluorophore) was not organelle-specific and the fluorescence intensity was very weak even at 2 µM concentration (Supporting Information File 1, Figure S18). Impact of compound 1 on cell viability
BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide
Beilstein J. Org. Chem. 2017, 13, 1316–1324, doi:10.3762/bjoc.13.128
- [14][15][16], drugs [17], cell organelle markers, for antibody, peptide and nucleic acid labelling [18][19][20], for pH [21], metal [22][23] and redox potential sensing (well-reviewed in Boens et al. [24]), as well as for the development of photodynamically active agents [25][26]. In this work, we
From chemical metabolism to life: the origin of the genetic coding process
Beilstein J. Org. Chem. 2017, 13, 1119–1135, doi:10.3762/bjoc.13.111
- blown centriole. This daughter organelle will then play the same role as that of the parent for organising chromosome distribution in the daughter cell. This structure is remarkable as it is apparently a protein-only structure that undergoes exact duplication. However, the parent structure is not used
Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans
Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243
- ; fluorescence; fusion; imaging; in vivo; microscopy; mitochondria; model organisms; organelle; rhodamine; spectroscopy; Introduction Fluorescent molecular probes represent critical tools for studies of chemical biology [1]. These compounds allow the creation of sensitive enzyme substrates, sensors of a wide
- , that are targeted to this organelle. In general, the choice to use small-molecule probes or molecular-biology-based approaches for these types of imaging applications can be challenging because of our limited understanding of the bioavailability and bioaccumulation of small molecules in this model
- labeling of tubular mitochondria surrounding the mitotic nuclei of the gonad can be observed as well as strong staining of mitochondria within oocytes (white arrows indicate the most proximal oocyte, where visible) and the fibrous organelle (marked with an asterisk in panel C) of spermatheca. Scale bar
Synthesis in the glycosciences II
Beilstein J. Org. Chem. 2012, 8, 411–412, doi:10.3762/bjoc.8.45
- to assemble as the oligosaccharides. And there is no other cell organelle that is less understood in its detailed biochemical function and the meaning of its supramolecular identity than the glycocalyx. Hence, the field of “glycomics” may comprise a rather infant field of the “omics era”, but it is
Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides
Beilstein J. Org. Chem. 2010, 6, No. 5, doi:10.3762/bjoc.6.5
- of protein–protein interactions is gaining interest as they are known to play a critical role in important biological processes such as the normal function of cellular/organelle structure, immune response, enzyme inhibitors, signal transduction, and apoptosis. Rational protein surface recognition
Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel
Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13
- microtubule organizing centers located near the cell periphery and the + ends located towards the chromosomes. This enables the microtubules to pull the daughter chromosomes apart during mitotic division. However, microtubules also play important roles in organelle transport, cell shape maintenance, and
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