Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization

• Axel G. Griesbeck,
• Lars-Oliver Höinck and
• Jörg M. Neudörfl

Beilstein J. Org. Chem. 2010, 6, No. 61, doi:10.3762/bjoc.6.61

• hydroperoxy alcohol 4 and benzaldehyde derivatives, was investigated by X-ray crystallography. Keywords: ene reaction; peracetalization; peroxides; singlet oxygen; trioxanes; Introduction The antimalaria-active molecule artemisinin (1) is a naturally occurring sesquiterpene peroxide with remarkable