Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole–tetrahydroxamic acid receptor

• Sara Karnib,
• Rana Baydoun,
• Wissam Zaidan,
• Nancy AlHaddad,
• Omar El Samad,
• Bilal Nsouli,
• Francine Cazier-Dennin and
• Pierre-Edouard Danjou

Beilstein J. Org. Chem. 2026, 22, 486–494, doi:10.3762/bjoc.22.36

• extractants. Here, we report the design and synthesis of PCP HA, a phenoxycalix[4]pyrrole scaffold functionalized with four hydroxamic acid (HA) groups, and evaluate its uranium(VI) extraction potential. PCP HA was synthesized from its ester precursor (PCP E) via hydroxyaminolysis using KOH, achieving a 95

• supramolecular material for the removal of uranyl from aqueous media. Keywords: gamma spectroscopy; hydroxamic acid; phenoxycalix[4]pyrrole; solid–liquid extraction; uranyl(VI) extraction; Introduction Over the past few decades, supramolecular chemistry has advanced intensively establishing itself as a central

• -hydroxyphenyl)calix[4]pyrrole, commonly referred to as phenoxycalix[4]pyrrole (PCP). It was first reported in 1999 by two independent research groups, Floriani et al. and Sessler et al., via the acid-catalyzed condensation of pyrrole with p-hydroxyacetophenone [17][18]. PCP and its derivatives were first known