Beilstein J. Org. Chem.2021,17, 461–484, doi:10.3762/bjoc.17.41
phosphonodepsipeptides with C-1-hydroxyalkylphosphonic acids.
Keywords: alkylation; mimetic; multicomponent condensation; peptide; phosphonopeptide; phosphonodepsipeptide; phosphonylation; Introduction
Both, phosphonopeptides and phosphonodepsipeptides are phosphorus analogues of peptides [1][2][3][4][5]. The
reaction of benzyl carbamate, aldehydes, and trialkyl phosphites in acetyl chloride gave rise to N-Cbz-1-aminoalkylphosphonates [40]. When the reactions were conducted in benzene followed by an aminolysis or alcoholysis, phosphonamidates [41], phosphonopeptide [42], and mixed esters [43][44] were obtained
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Graphical Abstract
Figure 1:
Phosphonopeptides, phosphonodepsipeptides, peptides, and depsipeptides.